Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043013208> ?p ?o ?g. }
- W2043013208 endingPage "4172" @default.
- W2043013208 startingPage "4159" @default.
- W2043013208 abstract "Inactivation is an inherent property of most voltage-gated K(+) channels. While fast N-type inactivation has been analyzed in biophysical and structural details, the mechanisms underlying slow inactivation are yet poorly understood. Here, we characterized a slow inactivation mechanism in various KCNQ1 pore mutants, including L273F, which hinders entry of external Ba(2+) to its deep site in the pore and traps it by slowing its egress. Kinetic studies, molecular modeling, and dynamics simulations suggest that this slow inactivation involves conformational changes that converge to the outer carbonyl ring of the selectivity filter, where the backbone becomes less flexible. This mechanism involves acceleration of inactivation kinetics and enhancement of Ba(2+) trapping at elevated external K(+) concentrations. Hence, KCNQ1 slow inactivation considerably differs from C-type inactivation where vacation of K(+) from the filter was invoked. We suggest that trapping of K(+) at s(1) due to filter rigidity and hindrance of the dehydration-resolvation transition underlie the slow inactivation of KCNQ1 pore mutants." @default.
- W2043013208 created "2016-06-24" @default.
- W2043013208 creator A5009653020 @default.
- W2043013208 creator A5018812721 @default.
- W2043013208 creator A5021819560 @default.
- W2043013208 creator A5027199610 @default.
- W2043013208 creator A5042786145 @default.
- W2043013208 creator A5053454568 @default.
- W2043013208 creator A5054988954 @default.
- W2043013208 creator A5059602749 @default.
- W2043013208 creator A5071739030 @default.
- W2043013208 creator A5082027756 @default.
- W2043013208 date "2007-12-01" @default.
- W2043013208 modified "2023-09-29" @default.
- W2043013208 title "An Inactivation Gate in the Selectivity Filter of KCNQ1 Potassium Channels" @default.
- W2043013208 cites W1233451781 @default.
- W2043013208 cites W1491033866 @default.
- W2043013208 cites W1517714742 @default.
- W2043013208 cites W1522477379 @default.
- W2043013208 cites W1601586027 @default.
- W2043013208 cites W1965504965 @default.
- W2043013208 cites W1966667742 @default.
- W2043013208 cites W1969152739 @default.
- W2043013208 cites W1969870358 @default.
- W2043013208 cites W1972126248 @default.
- W2043013208 cites W1974230313 @default.
- W2043013208 cites W1976825191 @default.
- W2043013208 cites W1980261438 @default.
- W2043013208 cites W1982019406 @default.
- W2043013208 cites W1982288571 @default.
- W2043013208 cites W1983137097 @default.
- W2043013208 cites W1983959184 @default.
- W2043013208 cites W1985800639 @default.
- W2043013208 cites W1990054795 @default.
- W2043013208 cites W1990737080 @default.
- W2043013208 cites W1995081108 @default.
- W2043013208 cites W2002422701 @default.
- W2043013208 cites W2010038788 @default.
- W2043013208 cites W2024244843 @default.
- W2043013208 cites W2027098366 @default.
- W2043013208 cites W2028884027 @default.
- W2043013208 cites W2036063596 @default.
- W2043013208 cites W2040083201 @default.
- W2043013208 cites W2041845061 @default.
- W2043013208 cites W2049288117 @default.
- W2043013208 cites W2052310626 @default.
- W2043013208 cites W2055395721 @default.
- W2043013208 cites W2060809301 @default.
- W2043013208 cites W2073892495 @default.
- W2043013208 cites W2097944725 @default.
- W2043013208 cites W2100977476 @default.
- W2043013208 cites W2104925034 @default.
- W2043013208 cites W2113789703 @default.
- W2043013208 cites W2117055264 @default.
- W2043013208 cites W2120269518 @default.
- W2043013208 cites W2122167535 @default.
- W2043013208 cites W2122438328 @default.
- W2043013208 cites W2124653618 @default.
- W2043013208 cites W2127735309 @default.
- W2043013208 cites W2129232461 @default.
- W2043013208 cites W2129903803 @default.
- W2043013208 cites W2131623830 @default.
- W2043013208 cites W2131840590 @default.
- W2043013208 cites W2133464980 @default.
- W2043013208 cites W2140894987 @default.
- W2043013208 cites W2141494494 @default.
- W2043013208 cites W2143070723 @default.
- W2043013208 cites W2144362290 @default.
- W2043013208 cites W2147885377 @default.
- W2043013208 cites W2152997847 @default.
- W2043013208 cites W2158172542 @default.
- W2043013208 cites W2158633534 @default.
- W2043013208 cites W2160867750 @default.
- W2043013208 cites W2162166182 @default.
- W2043013208 cites W2164829352 @default.
- W2043013208 cites W2165564780 @default.
- W2043013208 cites W2165970697 @default.
- W2043013208 cites W2166619667 @default.
- W2043013208 cites W2171548189 @default.
- W2043013208 doi "https://doi.org/10.1529/biophysj.107.107987" @default.
- W2043013208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2098732" @default.
- W2043013208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17704175" @default.
- W2043013208 hasPublicationYear "2007" @default.
- W2043013208 type Work @default.
- W2043013208 sameAs 2043013208 @default.
- W2043013208 citedByCount "29" @default.
- W2043013208 countsByYear W20430132082012 @default.
- W2043013208 countsByYear W20430132082013 @default.
- W2043013208 countsByYear W20430132082015 @default.
- W2043013208 countsByYear W20430132082016 @default.
- W2043013208 countsByYear W20430132082017 @default.
- W2043013208 countsByYear W20430132082018 @default.
- W2043013208 countsByYear W20430132082019 @default.
- W2043013208 countsByYear W20430132082020 @default.
- W2043013208 countsByYear W20430132082021 @default.
- W2043013208 countsByYear W20430132082022 @default.
- W2043013208 crossrefType "journal-article" @default.
- W2043013208 hasAuthorship W2043013208A5009653020 @default.