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- W2043015951 abstract "Abstract The relative ability of influenza HA DNA vaccines to induce cellular and humoral immunity after one or more doses and the persistence of this response have not been fully elucidated. HA DNA induces a potent Th1 response. Although this response wanes 12 weeks after a single immunisation, Th1 cells persist in the spleen for at least 6 months after two booster immunisations. In contrast, influenza specific ELISA IgG titres reached significant levels only after booster immunisations and HI antibodies were generally weak or undetectable. Nevertheless, two doses of HA DNA confer almost complete protection against respiratory challenge with live virus." @default.
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- W2043015951 date "2001-10-01" @default.
- W2043015951 modified "2023-09-27" @default.
- W2043015951 title "Influenza HA DNA induces Th1 cells and protection despite limited antibody responses" @default.
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- W2043015951 doi "https://doi.org/10.1016/s0531-5131(01)00367-3" @default.
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