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• W2043022038 abstract "Edaravone is a lipophilic drug with multiple mechanisms of action. Because edaravone is a promising drug candidate for the treatment of stroke, we tested the hypothesis that edaravone would be neuroprotective following cerebral ischemia using a rabbit embolic stroke model with a well-defined behavioral endpoint. Using the rabbit small clot embolic stroke model (RSCEM), a drug or drug combination is considered beneficial if it significantly increases the amount of microclots (mg) measured in brain that produce neurologic dysfunction in 50% of a group of animals (P50) compared to the control group. Edaravone (100 mg/kg, SC), increased the P50 value to 1.80 ± 0.24 mg (p < 0.05) when administered 5 min following embolization and increased P50 values by 195% and 161% (compared to control) when administered 1 and 3 h following embolization, respectively, but was inactive when applied 6 h following embolization, compared to the cumulative control group (P50 = 0.93 ± 0.16 mg). To simulate the design of current clinical trials, edaravone was also given following a standard tPA regimen, which by itself increased the P50 value to 2.72 ± 0.28 mg. When tPA was infused 1 h following embolization and edaravone was given 3 h following embolization, the P50 was 2.68 ± 0.56 mg. This study indicates that edaravone may have substantial therapeutic benefit for the treatment of AIS since it had a therapeutic widow of at least 3 h in rabbits. Edaravone can also be administered with a thrombolytic to improve behavior." @default.
• W2043022038 created "2016-06-24" @default.
• W2043022038 creator A5028934169 @default.
• W2043022038 creator A5060081589 @default.
• W2043022038 date "2009-01-01" @default.
• W2043022038 modified "2023-10-03" @default.
• W2043022038 title "The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: A combination therapy study with tissue plasminogen activator" @default.
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• W2043022038 doi "https://doi.org/10.1016/j.expneurol.2008.09.004" @default.
• W2043022038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18851964" @default.
• W2043022038 hasPublicationYear "2009" @default.
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