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- W2043022288 abstract "Tendon xanthomatosis often accompanies familial hypercholesterolaemia, but it can also occur in other pathologic states. Achilles tendons are the most common sites of tendon xanthomas. Low-density lipoprotein (LDL) derived from the circulation accumulates into tendons. The next steps leading to the formation of Achilles tendon xanthomas (ATX) are the transformation of LDL into oxidized LDL (oxLDL) and the active uptake of oxLDL by macrophages within the tendons. Although physical examination may reveal Achilles tendon xanthomas (ATX), there are several imaging methods for their detection. It is worth mentioning that ultrasonography is the method of choice in everyday clinical practice. Although several treatments for Achilles tendon xanthomas (ATX) have been proposed (LDL apheresis, statins, etc.), they target mostly in the treatment of the basic metabolic disorder of lipid metabolism, which is the main cause of these lesions. In this review we describe the formation, detection, differential diagnosis and treatment of ATX as well as the relationship between tendon xanthomas and atheroma." @default.
- W2043022288 created "2016-06-24" @default.
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- W2043022288 creator A5055033749 @default.
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- W2043022288 date "2005-04-01" @default.
- W2043022288 modified "2023-10-14" @default.
- W2043022288 title "Pathogenesis, detection and treatment of Achilles tendon xanthomas" @default.
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- W2043022288 doi "https://doi.org/10.1111/j.1365-2362.2005.01484.x" @default.
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