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• W2043042361 abstract "British Journal of Clinical PharmacologyVolume 34, Issue 4 p. 281-288 Free Access Diethylcarbamazine in the treatment of patients with onchocerciasis. K. Awadzi, K. Awadzi Onchocerciasis Chemotherapy Research Centre, Hohoe Hospital, Ghana.Search for more papers by this authorHM Gilles, HM Gilles Onchocerciasis Chemotherapy Research Centre, Hohoe Hospital, Ghana.Search for more papers by this author K. Awadzi, K. Awadzi Onchocerciasis Chemotherapy Research Centre, Hohoe Hospital, Ghana.Search for more papers by this authorHM Gilles, HM Gilles Onchocerciasis Chemotherapy Research Centre, Hohoe Hospital, Ghana.Search for more papers by this author First published: October 1992 https://doi.org/10.1111/j.1365-2125.1992.tb05632.xCitations: 19AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References Adams, J. C. L. & Woodruff, A. W. (1953). Diethylcarbamazine in the treatment of onchocerciasis. Trans. Soc. Trop. Med. Hyg., 47, 66– 69. Albiez, E. J., Walter, G., Kaiser, A., Newland, H. S., White, A. T., Greene, B. M., Taylor, H. R. & Buttner, D. W. (1988). Effects of high doses of diethylcarbamazine on adult Onchocerca volvulus by the collagenase technique and by histology. Trop. Med. Parasit., 39, 87– 92. Anderson, J. & Fuglsang, H. (1973). Topical diethylcarbamazine in ocular onchocerciasis. Trans. Soc. Trop. Med. Hyg., 67, 710– 717. Anderson, J., Fuglsang, H. & Marshall, T. F. de C. (1976). Effects of diethylcarbamazine on ocular onchocerciasis. Trop. Med. Parasit., 27, 263– 278. Aviel, E. & David, R. (1972). Topical diethylcarbamazine in ocular onchocerciasis. Isr. J. med. Sci., 8, 1166– 1168. Awadzi, K. (1980). The chemotherapy of onchocerciasis. II. Quantitation of the clinical reaction to microfilaricides. Ann. Trop. med. Parasitol., 74, 189– 197. Awadzi, K., Adjepon-Yamoah, K. K., Edwards, G., Orme. M.L.E., Breckenridge, A. M. & Gilles, H. M. (1986). The effect of moderate urine alkalinisation on low dose diethylcarbamazine therapy in patients with onchocerciasis. Br. J. clin. Pharmac., 21, 669– 676. Awadzi, K., Dadzie, K. Y., Schulz-Key, H., Gilles, H. M., Fulford, A. J. & Aziz, M. A. (1986). The chemotherapy of onchocerciasis XI: A double-blind comparative study of ivermectin, diethylcarbamazine and placebo in human onchocerciasis in northern Ghana. Ann. Trop. med. Parasitol., 80, 433– 442. Awadzi, K., Orme, M. L'E., Breckenridge, A. M. & Gilles, H. M. (1982a). The chemotherapy of onchocerciasis VI: The effects of indomethacin and cyproheptadine on the Mazzotti reaction. Ann. Trop. med. Parasitol., 76, 323– 330. Awadzi, K., Orme, M.L'E., Breckenridge, A. M. & Gilles, H. M. (1982b). The chemotherapy of onchocerciasis VII: The effect of prednisone on the Mazzotti reaction. Ann. Trop. med. Parasitol., 76, 331– 338. Awadzi, K., Orme, M. L'E., Breckenridge, A. M. & Gilles, H. M. (1982c). The chemotherapy of onchocerciasis IX: The effect of prednisone plus cyproheptadine on the Mazzotti reaction. Ann. Trop. med. Parasitol., 76, 547– 555. Ben-Sira, I., Aviel, E., Lazar, M., Liebermann, T. W. & Leopold, I. H. (1970). Topical hetrazan in the treatment of onchocerciasis. Am. J. Ophthalmol., 70, 741– 743. Bernhard, J. A., Figueroa, G. L. N. & Garcia Manzo, A. (1964). Triamcinolona como profilactico en las reacciones secundarias producidas por le hetrazan. Salud. Publica, Mexico, 6, 835– 841. Bird, A. C., El Sheikh, H., Anderson, J. & Fuglsang, H. (1980). Changes in visual function and in the posterior segment of the eyes during treatment of onchocerciasis with diethylcarbamazine-citrate. Br. J. Ophthalmol., 64, 191– 200. Bryceson, A. D. M., Warrell, D. A. & Pope, H. M. (1977). Dangerous reactions to treatment of onchocerciasis with diethylcarbamazine. Br. med. J., 1, 742– 744. Campbell, W. C. (1991). Ivermectin as an antiparasitic agent for use in humans. Ann. Rev. Microbiol., 45, 445– 474. Dadzie, K. Y., Bird, A. C., Awadzi, K., Schulz-Key, H., Gilles, H. M. & Aziz, M. A. (1987). Ocular findings in a double-blind study of ivermectin versus diethylcarbamazine versus placebo in the treatment of onchocerciasis. Br. J. Ophthalmol., 71, 78– 85. Diallo, S., Aziz, M. A., Lariviere, M., Diallo, J. S., Diop-Mar, I., N'dir, O., Badiane, S., Py, D., Schulz-Key, H., Gaxotte, P. & Victorius, A. (1986). A double-blind comparison of the efficacy and safety of ivermectin, and diethylcarbamazine in a placebo controlled study of Senegalese patients with onchocerciasis. Trans. Soc. Trop. med. Hyg., 80, 927– 934. Duke, B. O. L. (1957). The reapparance, rate of increase and distribution of the microfilariae of Onchocerca volvulus following treatment with diethylcarbamazine. Trans. Soc. Trop. Med. Hyg., 51, 37– 44. Duke, B. O. L. (1968). The effects of drugs on Onchocerca volvulus. 1. Methods of assessment, population dynamics of the parasite and the effects of diethylcarbamazine. Bull. W. H. O. 39, 137– 146. Duke, B. O. L. & Anderson, J. (1972). Onchocerciasis and its treatment. Trop. Doct., 2, 107– 114. Duke, B. O. L. & Anderson, J. (1975). Onchocerciasis. Trop. Doct., 5, 141– 142. Edwards, G., Awadzi, K., Breckenridge, A. M., Gilles, H. M., Orme, M. L. E. & Ward, S. A. (1981a). Diethylcarbamazine disposition in patients with onchoceriasis. Clin. Pharmac. Ther., 30, 551– 557. Edwards, G. & Breckenridge, A. M. (1988). Clinical pharmacokinetics of anthelmintic drugs. Clin. Pharmacokin., 15, 67– 93. Edwards, G., Breckenridge, A. M., Adjepon-Yamoah, K. K., Orme, M. L'E. & Ward, S. A. (1981b). The effect of variations in urinary pH on the pharmacokinetics of diethylcarbamazine. Br. J. clin. Pharmac., 12, 807– 812. Francis, H., Awadzi, K. & Ottesen, E. A. (1985) The Mazzotti reaction following treatment of onchocerciasis with diethylcarbamazine: clinical severity as a function of infection intensity. Am. J. Trop. med. Hyg., 34, 529– 536. Fuglsang, H. & Anderson, J. (1974). Collapse during treatment of onchocerciasis with diethylcarbamazine. Trans. Soc. Trop. med. Hyg., 68, 72– 73. Fuglsang, H. & Anderson, J. (1976). Deseril and diethylcarbamazine in the treatment of onchocerciasis. Trans. Soc. Trop. med. Hyg., 70, 534. Fulford, A. J. C., Macfarlane, S. B. J., Awadzi, K., Bell, D. R. & Gilles, H. M. (1987). The prediction of microfilarial loads in patients with onchocerciasis after treatment with diethylcarbamazine in Northern Ghana. Ann. Trop. med. Parasitol., 81, 710– 711. Garcia Manzo, A., Fugueroa, G. L. N. & Bernhard, J. A. (1965). El uso del fosfato de betametosona para controlar las reacciones secudarias produciadas por hetrazan en pacientes oncocercosos. Salud Publica, Mexico, 7, 209– 212. Greene, B. M., Taylor, H. R., Cupp, E. W., Murphy, R. P., White, A. T., Aziz, M. A., Schulz-Key, H., D'Anna, S. A., Newland, H. S., Goldschmidt, L. P., Auer, C., Hanson, A. P., Freeman, S. V., Reber, E. W. & Williams, P. N. (1985). Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. New Engl. J. Med., 313, 133– 138. Guerra-Caceres, J. G., Bryceson, A. D. M., Quakyi, I. & Spry, C. J. F. (1980). Studies on the mechanisms of adverse reactions produced by diethylcarbamazine in patients with onchocerciasis-Mazzotti reaction. Parasite Immunol., 2, 121– 131. Hawking, F. (1952). A histological study of onchocerciasis treated with hetrazan. Br. med. J., 1, 992– 994. Henson, P., Mackenzie, C. D. & Spector, W. G. (1979). Inflammatory reactions in onchocerciasis: a report on current knowledge and recommendations for further study. Bull. W.H.O., 57, 667– 682. Hero, M., Bird, A. C. & Awadzi, K. (1992). Quantification of the ocular reactions to microfilaricides in the chemotherapy of onchocerciasis. Eye, 6, 93– 96. Hutchinson, D. B. A., El Sheikh, H., Jones, B. R., Anderson, J., Fuglsang, H. & Mackenzie, C. D. (1979). Adverse reactions to cutaneous diethylcarbamazine in onchocerciasis. Lancet, ii, 46. Jones, B. R., Anderson, J. & Fuglsang, H. (1978). Effects of various concentrations of diethylcarbamazine citrate applied as eye drops in ocular onchocerciasis and the possibilities of improved therapy from continuous non- pulsed delivery. Br. J. Ophthalmol., 62, 428– 439. Lagraulet, J., Monjusiau, A. & Durand, B. (1964). Etude clinique de l'action du methysegide sur le choc thera-peutique a la diethylcarbamazine dans l'onchocercose (Essai preliminaire). Bull. Soc. Path. Exot, 57, 528– 536. Langham, M. E. & Beltranena, F. (1985). The Onchocerca volvulus micro- and macrofilarial responses in onchocerciasis patients to increased dosage of diethylcarbamazine. Tropenmed. Parasitol., 36, 175– 179. Langham, M. E., Traub, Z. D. & Richardson, R. (1978). A transepidermal chemotherapy of onchocerciasis. Tropenmed. Parasitol., 29, 159– 162. Lariviere, M., Vingtain, P., Aziz, M. A., Beauvais, B., Weimann, D., Derouin, F., Ginoux, J., Schulz-Key, H., Gaxotte, P., Bassett, O. & Sarafti, C. (1985). Double-blind study of ivermectin and diethylcarbamazine in African onchocericasis patients with ocular involvement. Lancet, ii, 174– 177. Markell, E. K. & Turner, J. (1957). Cortisone and prednisone in the suppresion of allergic reactions to diethylcarbamazine treatment of onchocerciasis. Am. J. Trop. med. Hyg., 6, 546– 552. Martinez Baez, M. (1952). Accion del hetrazan sobre Onchocerca volvulus al estado adulto. Medicina; Revista Mexicana, 32, 521– 523. Martinez Baez, M. (1953). Neuvos datos acerca de la accion del hetrazan sobre Onchocerca volvulus al estado adulto. Revista del Instituto Salubridad Enfermedades Tropicales, 13, 71– 75. Mazzotti, L. (1948). 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P. & Desfontaine, M. (1979b). Chimotherapie de l'onchocercose. II. Evaluation de l'activite de deux schemas therapeu-tiques associant diethylcarbamazine + levamisole sur la densite microfilarienne d'Onchocerca volvulus (Leukart, 1893). Med. Trop., 39, 631– 635. Ree, G. H. (1977). Onchocerciasis treated with diethylcarbamazine Br. J. Dermatol., 97, 551– 554. Rougemont, A., Boisson, M. E., Borges da Silva, G. & Zander, N. (1976). Un essai de traitement collectif par la diethylcarbamazine dans un village d'hyperendemie onchocequinine de la region de Bamako (Mali). Bull. W.H.O., 54, 403– 410. Salazar Mallen, M., Molina Pasquel, C. & Chavez Nunez, M. (1962). Profilaxis del choque terapeutico producido por la dietilcarbamazina. Salud Publica. Mexico, 4, 1065– 1069. Salazar Mallen, M. & Chevez Zamora, A. (1965). Estudios clinicos immunologicos, quimicos y farmacologicos del choque terapeutico producido por dietilcarbamazina en la oncocercosis. Revista del Instituto de Salubridad Enfermedades Tropicales, 25, 163– 169. Sowa, J. & Sowa, S. C. I. (1978). Long term treatment of onchocerciasis in children with low doses of diethylcarbamazine. Ann. Trop. med. Parasitol., 72, 79– 85. Taylor, H. R., Greene, B. M. & Langham, M. E. (1980). Controlled clinical trial of oral and topical diethylcarbamazine in the treatment of onchocercias. Lancet, i, 943– 946. Torroella, J. (1964). Resultado de la aplicacion en el campo de la dietilcarbamazina asocida al clorhidrato de metdilazina y triamcinolona. Salud Publica. Mexico, 6, 595– 597. Villamayor, C. A. (1963). La ciproheptadina en el control de reacciones secundarias a la terapeutica antioncocercosa con dietilcarbamazina. Boletin Epidemiologico. Mexico, 27, 76– 80. Villamayor, C. A. (1970). Estudio para valorar la prevencion del choque terapeutico en la encocercosis. Salud Publica. Mexico, 12, 321– 331. World Health Organisation. (1987). Expert committee on onchocerciasis. Third Report. Technical Report Series, No 752, 54– 64. Citing Literature Volume34, Issue4October 1992Pages 281-288 ReferencesRelatedInformation" @default.
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