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• W2043043206 abstract "Background: Fibroproliferative disorders, such as Dupuytren’s contracture of the hand, are characterized by excessive production of collagen. 5-Fluorouracil has been used to treat fibroproliferative disorders of the eye and skin and is thought to inhibit thymidylate synthetase blocking DNA replication. 5-Fluorouracil has been shown to down-regulate fibroblast proliferation and differentiation in vitro. Methods: This study investigated the dose-dependent effect of 5-fluorouracil on fibroblast extracellular matrix production. Fibroblasts were derived from tendon and primary Dupuytren’s disease of the hand, a fibroproliferative disorder of the palmar aponeurosis (n = 4 patients). Total collagen synthesis was determined by means of the incorporation of radiolabeled proline. Fibroblast secretion of the profibrotic factor transforming growth factor-β1 (TGF-β1) was measured by a sandwich enzyme-linked immunosorbent assay. Gene expression of collagen types I and III and TGF-β1 were quantified by means of reverse-transcriptase polymerase chain reaction assays. Results: The authors found that 5-fluorouracil caused a dose-dependent, selective, and specific decrease in collagen production by Dupuytren’s fibroblasts compared with noncollagenous protein synthesis. By contrast, procollagen types I and III mRNA were unaffected by 5-fluorouracil treatment. These changes did not appear to be mediated by alterations in the endogenous secretion of TGF-β1 or its autocrine effect on collagen metabolism. Conclusions: The clinical implication is that 5-fluorouracil could possibly reduce extracellular matrix production and therefore reduce recurrence of Dupuytren’s disease of the hand." @default.
• W2043043206 created "2016-06-24" @default.
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• W2043043206 date "2005-07-01" @default.
• W2043043206 modified "2023-09-27" @default.
• W2043043206 title "5-Fluorouracil Selectively Inhibits Collagen Synthesis" @default.
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• W2043043206 doi "https://doi.org/10.1097/01.prs.0000169701.16509.d6" @default.
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