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- W2043043757 abstract "A target is druggable if it can be modulated in vivo by a drug-like molecule. The general properties of oral drugs are summarized by the 'rule of 5' which specifies parameters related to size and lipophilicity. Structure-based target druggability assessment consists of predicting ligand-binding sites on the protein that are complementary to these drug-like properties. Automated identification of ligand-binding sites can use geometrical considerations alone or include specific physicochemical properties of the protein surface. Features of a pocket's size and shape, together with measures of its hydrophobicity, are most informative in identifying suitable drug-binding pockets. The recent availability of several validation sets of druggable versus undruggable targets has helped fuel the development of more elaborate methods." @default.
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- W2043043757 date "2011-08-01" @default.
- W2043043757 modified "2023-10-06" @default.
- W2043043757 title "Structure-based druggability assessment—identifying suitable targets for small molecule therapeutics" @default.
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- W2043043757 doi "https://doi.org/10.1016/j.cbpa.2011.05.020" @default.
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