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- W2043048557 abstract "Liposomes have been used as biological carriers of antitumor drugs, and their potential use has been tested using various mouse tumors. In this study, we describe a potential role of liposome-encapsulated 1-beta-D-arabinofuranosylcytosine (Ara-C) with a mouse solid lung tumor model. Non-encapsulated Ara-C at 25 mg/kg dose by the intraperitoneal (i.p.) route on days 1, 4 and 7 had no improving effect on the average survival time of tumor-bearing mice compared to untreated control mice. However, the same dose of Ara-C encapsulated in multilamellar liposomes (MLV) improved the average survival of tumor-bearing mice by 60 to 80%. Ara-C was encapsulated more efficiently when DSPC or DPPC MLV were prepared at temperatures below their respective transition temperatures. DSPC and DPPC MLV prepared at 25 degrees C and DPPC MLV prepared at 50 degrees C were equally effective for in vivo therapy, while DSPC MLV prepared at 60 degrees C were not as effective. Non-specific immunotherapy using BCG (Bacillus Calmette-Guérin, Mycobacterium tuberculosis) and CP Corynebacterium parvum) was effective, particularly when injected by the intravenous (i.v.) route, in prolonging the average survival of tumor-bearing mice. A combination of either i.v. BCG or i.p. CP with liposome therapy gave no further improvement in the average survival of tumor-bearing mice. However, a combination of either i.p. BCG or i.v. CP with liposome therapy was somewhat more effective than either liposome therapy or immunotherapy alone." @default.
- W2043048557 created "2016-06-24" @default.
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- W2043048557 date "1984-09-01" @default.
- W2043048557 modified "2023-09-24" @default.
- W2043048557 title "Treatment of intravenously implanted lewis lung carcinoma with liposome-encapsulated cytosine arabinoside and non-specific immunotherapy" @default.
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- W2043048557 doi "https://doi.org/10.1002/ijc.2910340320" @default.
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