FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043055866> ?p ?o ?g. }

• W2043055866 endingPage "471" @default.
• W2043055866 startingPage "463" @default.
• W2043055866 abstract "Cellular thyroid hormone uptake and efflux are mediated by transmembrane transport proteins. One of these, monocarboxylate transporter 8 (MCT8) is mutated in Allan-Herndon-Dudley syndrome, a severe mental retardation associated with abnormal thyroid hormone constellations. Since mice deficient in Mct8 exhibit a milder neurological phenotype than patients, we hypothesized that alternative thyroid hormone transporters may compensate in murine brain cells for the lack of Mct8. Using qPCR, Western Blot, and immunocytochemistry, we investigated the expression of three different thyroid hormone transporters, i.e., Mct8 and L-type amino acid transporters Lat1 and Lat2, in mouse brain. All three thyroid hormone transporters are expressed from corticogenesis and peak around birth. Primary cultures of neurons and astrocytes express Mct8, Lat1, and Lat2. Microglia specifically expresses Mct10 and Slco4a1 in addition to high levels of Lat2 mRNA and protein. As in vivo, a brain microvascular endothelial cell line expressed Mct8 and Lat1. 158N, an oligodendroglial cell line expressed Mct8 protein, consistent with delayed myelination in MCT8-deficient patients. Functional T(3)- and T(4)-transport assays into primary astrocytes showed K(M) values of 4.2 and 3.7 μM for T(3) and T(4). Pharmacological inhibition of L-type amino acid transporters by BCH and genetic inactivation of Lat2 reduced astrocytic T(3) uptake to the same extent. BSP, a broad spectrum inhibitor, including Mct8, reduced T(3) uptake further suggesting the cooperative activity of several T(3) transporters in astrocytes." @default.
• W2043055866 created "2016-06-24" @default.
• W2043055866 creator A5001832696 @default.
• W2043055866 creator A5015780834 @default.
• W2043055866 creator A5019435104 @default.
• W2043055866 creator A5029064337 @default.
• W2043055866 creator A5048650129 @default.
• W2043055866 creator A5052536282 @default.
• W2043055866 creator A5076092368 @default.
• W2043055866 creator A5079022262 @default.
• W2043055866 date "2010-12-29" @default.
• W2043055866 modified "2023-10-06" @default.
• W2043055866 title "Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells" @default.
• W2043055866 cites W1633610692 @default.
• W2043055866 cites W1900556344 @default.
• W2043055866 cites W1972233047 @default.
• W2043055866 cites W1973870850 @default.
• W2043055866 cites W1975345061 @default.
• W2043055866 cites W1983512668 @default.
• W2043055866 cites W1988982593 @default.
• W2043055866 cites W1992268803 @default.
• W2043055866 cites W1996045753 @default.
• W2043055866 cites W2000741536 @default.
• W2043055866 cites W2008097674 @default.
• W2043055866 cites W2009215735 @default.
• W2043055866 cites W2012826020 @default.
• W2043055866 cites W2017632004 @default.
• W2043055866 cites W2023134890 @default.
• W2043055866 cites W2023919169 @default.
• W2043055866 cites W2028200173 @default.
• W2043055866 cites W2032940004 @default.
• W2043055866 cites W2035272476 @default.
• W2043055866 cites W2036549380 @default.
• W2043055866 cites W2043554769 @default.
• W2043055866 cites W2046152275 @default.
• W2043055866 cites W2052693888 @default.
• W2043055866 cites W2062347722 @default.
• W2043055866 cites W2062980259 @default.
• W2043055866 cites W2071264379 @default.
• W2043055866 cites W2076404268 @default.
• W2043055866 cites W2088145955 @default.
• W2043055866 cites W2088566177 @default.
• W2043055866 cites W2089231939 @default.
• W2043055866 cites W2090755454 @default.
• W2043055866 cites W2093446645 @default.
• W2043055866 cites W2094704242 @default.
• W2043055866 cites W2102129489 @default.
• W2043055866 cites W2108759450 @default.
• W2043055866 cites W2110110130 @default.
• W2043055866 cites W2126963608 @default.
• W2043055866 cites W2127859037 @default.
• W2043055866 cites W2159439402 @default.
• W2043055866 cites W2160488497 @default.
• W2043055866 cites W2165131597 @default.
• W2043055866 cites W2170601242 @default.
• W2043055866 cites W2188802626 @default.
• W2043055866 cites W4251306564 @default.
• W2043055866 cites W4253399987 @default.
• W2043055866 cites W84630634 @default.
• W2043055866 doi "https://doi.org/10.1002/glia.21116" @default.
• W2043055866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21264952" @default.
• W2043055866 hasPublicationYear "2010" @default.
• W2043055866 type Work @default.
• W2043055866 sameAs 2043055866 @default.
• W2043055866 citedByCount "105" @default.
• W2043055866 countsByYear W20430558662012 @default.
• W2043055866 countsByYear W20430558662013 @default.
• W2043055866 countsByYear W20430558662014 @default.
• W2043055866 countsByYear W20430558662015 @default.
• W2043055866 countsByYear W20430558662016 @default.
• W2043055866 countsByYear W20430558662017 @default.
• W2043055866 countsByYear W20430558662018 @default.
• W2043055866 countsByYear W20430558662019 @default.
• W2043055866 countsByYear W20430558662020 @default.
• W2043055866 countsByYear W20430558662021 @default.
• W2043055866 countsByYear W20430558662022 @default.
• W2043055866 countsByYear W20430558662023 @default.
• W2043055866 crossrefType "journal-article" @default.
• W2043055866 hasAuthorship W2043055866A5001832696 @default.
• W2043055866 hasAuthorship W2043055866A5015780834 @default.
• W2043055866 hasAuthorship W2043055866A5019435104 @default.
• W2043055866 hasAuthorship W2043055866A5029064337 @default.
• W2043055866 hasAuthorship W2043055866A5048650129 @default.
• W2043055866 hasAuthorship W2043055866A5052536282 @default.
• W2043055866 hasAuthorship W2043055866A5076092368 @default.
• W2043055866 hasAuthorship W2043055866A5079022262 @default.
• W2043055866 hasBestOaLocation W20430558661 @default.
• W2043055866 hasConcept C104317684 @default.
• W2043055866 hasConcept C126322002 @default.
• W2043055866 hasConcept C134018914 @default.
• W2043055866 hasConcept C149011108 @default.
• W2043055866 hasConcept C189613389 @default.
• W2043055866 hasConcept C2776678969 @default.
• W2043055866 hasConcept C2777542381 @default.
• W2043055866 hasConcept C2781217356 @default.
• W2043055866 hasConcept C526584372 @default.
• W2043055866 hasConcept C529278444 @default.
• W2043055866 hasConcept C55493867 @default.

• next