FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043060079> ?p ?o ?g. }

• W2043060079 endingPage "16134" @default.
• W2043060079 startingPage "16129" @default.
• W2043060079 abstract "In haloarchaea, light-driven ion transporters have been modified by evolution to produce sensory receptors that relay light signals to transducer proteins controlling motility behavior. The proton pump bacteriorhodopsin and the phototaxis receptor sensory rhodopsin II (SRII) differ by 74% of their residues, with nearly all conserved residues within the photoreactive retinal-binding pocket in the membrane-embedded center of the proteins. Here, we show that three residues in bacteriorhodopsin replaced by the corresponding residues in SRII enable bacteriorhodopsin to efficiently relay the retinal photoisomerization signal to the SRII integral membrane transducer (HtrII) and induce robust phototaxis responses. A single replacement (Ala-215-Thr), bridging the retinal and the membrane-embedded surface, confers weak phototaxis signaling activity, and the additional two (surface substitutions Pro-200-Thr and Val-210-Tyr), expected to align bacteriorhodopsin and HtrII in similar juxtaposition as SRII and HtrII, greatly enhance the signaling. In SRII, the three residues form a chain of hydrogen bonds from the retinal's photoisomerized C(13)=C(14) double bond to residues in the membrane-embedded alpha-helices of HtrII. The results suggest a chemical mechanism for signaling that entails initial storage of energy of photoisomerization in SRII's hydrogen bond between Tyr-174, which is in contact with the retinal, and Thr-204, which borders residues on the SRII surface in contact with HtrII, followed by transfer of this chemical energy to drive structural transitions in the transducer helices. The results demonstrate that evolution accomplished an elegant but simple conversion: The essential differences between transport and signaling proteins in the rhodopsin family are far less than previously imagined." @default.
• W2043060079 created "2016-06-24" @default.
• W2043060079 creator A5059177152 @default.
• W2043060079 creator A5084168263 @default.
• W2043060079 date "2006-10-31" @default.
• W2043060079 modified "2023-10-16" @default.
• W2043060079 title "Three strategically placed hydrogen-bonding residues convert a proton pump into a sensory receptor" @default.
• W2043060079 cites W1500671678 @default.
• W2043060079 cites W1513453028 @default.
• W2043060079 cites W1521824192 @default.
• W2043060079 cites W1807068310 @default.
• W2043060079 cites W1963480398 @default.
• W2043060079 cites W1972918885 @default.
• W2043060079 cites W1977401972 @default.
• W2043060079 cites W1978545530 @default.
• W2043060079 cites W1980583000 @default.
• W2043060079 cites W1996936744 @default.
• W2043060079 cites W1998561993 @default.
• W2043060079 cites W1999116701 @default.
• W2043060079 cites W1999734076 @default.
• W2043060079 cites W2012760852 @default.
• W2043060079 cites W2014915032 @default.
• W2043060079 cites W2016332472 @default.
• W2043060079 cites W2028410153 @default.
• W2043060079 cites W2031757246 @default.
• W2043060079 cites W2041701790 @default.
• W2043060079 cites W2044304587 @default.
• W2043060079 cites W2044706066 @default.
• W2043060079 cites W2051981823 @default.
• W2043060079 cites W2052338944 @default.
• W2043060079 cites W2062281714 @default.
• W2043060079 cites W2065105100 @default.
• W2043060079 cites W2068522285 @default.
• W2043060079 cites W2072590703 @default.
• W2043060079 cites W2077103862 @default.
• W2043060079 cites W2082996713 @default.
• W2043060079 cites W2083422052 @default.
• W2043060079 cites W2086360615 @default.
• W2043060079 cites W2086780082 @default.
• W2043060079 cites W2094211893 @default.
• W2043060079 cites W2098400255 @default.
• W2043060079 cites W2110057090 @default.
• W2043060079 cites W2111361043 @default.
• W2043060079 cites W2115357061 @default.
• W2043060079 cites W2124760611 @default.
• W2043060079 cites W2125190443 @default.
• W2043060079 cites W2136790557 @default.
• W2043060079 cites W2141539408 @default.
• W2043060079 cites W2145275570 @default.
• W2043060079 cites W2149992096 @default.
• W2043060079 cites W2160633484 @default.
• W2043060079 cites W2436690735 @default.
• W2043060079 doi "https://doi.org/10.1073/pnas.0607467103" @default.
• W2043060079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1637548" @default.
• W2043060079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17050685" @default.
• W2043060079 hasPublicationYear "2006" @default.
• W2043060079 type Work @default.
• W2043060079 sameAs 2043060079 @default.
• W2043060079 citedByCount "103" @default.
• W2043060079 countsByYear W20430600792012 @default.
• W2043060079 countsByYear W20430600792013 @default.
• W2043060079 countsByYear W20430600792014 @default.
• W2043060079 countsByYear W20430600792015 @default.
• W2043060079 countsByYear W20430600792016 @default.
• W2043060079 countsByYear W20430600792017 @default.
• W2043060079 countsByYear W20430600792018 @default.
• W2043060079 countsByYear W20430600792019 @default.
• W2043060079 countsByYear W20430600792020 @default.
• W2043060079 countsByYear W20430600792021 @default.
• W2043060079 countsByYear W20430600792023 @default.
• W2043060079 crossrefType "journal-article" @default.
• W2043060079 hasAuthorship W2043060079A5059177152 @default.
• W2043060079 hasAuthorship W2043060079A5084168263 @default.
• W2043060079 hasBestOaLocation W20430600791 @default.
• W2043060079 hasConcept C112887158 @default.
• W2043060079 hasConcept C12554922 @default.
• W2043060079 hasConcept C126661725 @default.
• W2043060079 hasConcept C161790260 @default.
• W2043060079 hasConcept C178790620 @default.
• W2043060079 hasConcept C185592680 @default.
• W2043060079 hasConcept C189542057 @default.
• W2043060079 hasConcept C200206546 @default.
• W2043060079 hasConcept C202033177 @default.
• W2043060079 hasConcept C2778113554 @default.
• W2043060079 hasConcept C2780827179 @default.
• W2043060079 hasConcept C32909587 @default.
• W2043060079 hasConcept C41625074 @default.
• W2043060079 hasConcept C55493867 @default.
• W2043060079 hasConcept C59822182 @default.
• W2043060079 hasConcept C8010536 @default.
• W2043060079 hasConcept C85311670 @default.
• W2043060079 hasConcept C86803240 @default.
• W2043060079 hasConceptScore W2043060079C112887158 @default.
• W2043060079 hasConceptScore W2043060079C12554922 @default.
• W2043060079 hasConceptScore W2043060079C126661725 @default.
• W2043060079 hasConceptScore W2043060079C161790260 @default.
• W2043060079 hasConceptScore W2043060079C178790620 @default.
• W2043060079 hasConceptScore W2043060079C185592680 @default.

• next