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• W2043060519 startingPage "207" @default.
• W2043060519 abstract "Bisphenol A (BPA) levels have previously been associated with coronary heart disease (CHD). Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study.In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), the prevalence of overt plaques and echogenectity (grey scale median, GSM) of carotid artery plaques were recorded by ultrasound in both of the carotid arteries. The thickness (IMT) and echogenicity (IM-GSM) of the intima-media complex were also measured. Bisphenol A (BPA) and 10 phthalate metabolites were analyzed in serum by a API 4000 liquid chromatograph/tandem mass spectrometer.Mono-methyl phthalate (MMP) was related to carotid plaques in an inverted U-shaped manner. This pattern was significant after adjustment for gender, body mass index, blood glucose, blood pressure, HDL and LDL-cholesterol, serum triglycerides, smoking, antihypertensive treatment and statin use (p=0.004). High levels of BPA, mono-isobutyl phthalate (MiBP) and MMP were associated with an echogenic IM-GSM and plaque GSM, while high levels of mono-2-ethylhexyl phthalate (MEHP) were associated with an echolucent IM-GSM and plaque GSM (p<0.0001 after adjustment).The phthalate metabolite MMP was related to atherosclerotic plaques in an inverted U-shaped manner independently of CV risk factors. Some phthalates and BPA were also related to the echogenicity of the plaques, suggesting a role for plaque-associated chemicals in atherosclerosis." @default.
• W2043060519 created "2016-06-24" @default.
• W2043060519 creator A5015851170 @default.
• W2043060519 creator A5069086729 @default.
• W2043060519 date "2011-09-01" @default.
• W2043060519 modified "2023-10-17" @default.
• W2043060519 title "Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly" @default.
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• W2043060519 doi "https://doi.org/10.1016/j.atherosclerosis.2011.05.001" @default.
• W2043060519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21621210" @default.
• W2043060519 hasPublicationYear "2011" @default.
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