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- W2043071046 abstract "The frequency of kernicterus following the administration of different antimicrobial drugs was studied in homozygous infant Gunn rats. Survival rate, weight gain, serum bilirubin and cerebral/cerebellar weight were measured. Kernicterus was studied in the cerebella of the animals by grading the loss of Purkinje cells using histochemical methods for the demonstration of oxydative enzymes (NADH-Tetrazolium reductase; LDH). Some gentamycin preparations containing great amounts of the stabilizer benzylalcohol produce a decrease in serum bilirubin levels to 50 % of the baseline concentration of 7-9 mg%. At the same time there is a marked increase in frequency and severity of kernicterus in these animals. Gentamycin without stabilizer had no such effect. Semi synthetic penicillins (oxacillin, cloxacillin, flucloxacillin, ampicillin, carbenicillin) had only little effect on serum bilirubin levels when given as single injection. The rate of kernicterus in homozygous Gunn rats was enhanced only when a combination of several semi synthetic penicillins was given. The changes of bilirubin concentrations and the rate of kernicterus observed in our experiments are the result of the displacement of bilirubin from its binding site to albumin. This can be produced by the stabilizer (beuzylalcohol) or by the drug itself (semi synthetic penicillins). Unbound (free) bilirubin is shifted into the brain immediately, where it can produce kernicterus." @default.
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- W2043071046 date "1976-10-01" @default.
- W2043071046 modified "2023-10-18" @default.
- W2043071046 title "73: Increased kernicterus rate in homozygous Gunn rats after application of different antibiotics" @default.
- W2043071046 doi "https://doi.org/10.1203/00006450-197610000-00067" @default.
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