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- W2043082642 abstract "Abstract The cellular origin of dysiherbaine, a marine‐sponge toxin, was investigated immunohistochemically by using an anti‐dysiherbaine antibody. Dysiherbaine‐like immunoreactivity was found to be localized in spherical cells harbored in the sponge mesohyl. A combination of ribosomal RNA gene (rDNA) analysis and cell‐morphology analysis revealed that the spherical cells were Synechocystis cyanobacteria. However, the sponge, identified as Lendenfeldia chondrodes on the basis of its rDNA sequence, appeared to contain two different chemotypes—dysiherbaine‐producing (DH + ) and nondysiherbaine‐producing (DH − )—both of which inhabited the same region. Synechocystis cells in the DH − sponge were not labeled with antibody, although the 16S rDNA gene profile of the cyanobacteria in the DH − sponge was indistinguishable from that of the cyanobacteria in the DH + sponge. On the basis of these results, we hypothesize that dysiherbaine is a metabolite of certain varieties of endosymbiotic Synechocystis sp." @default.
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- W2043082642 date "2008-02-21" @default.
- W2043082642 modified "2023-10-16" @default.
- W2043082642 title "Cellular Origin of Dysiherbaine, an Excitatory Amino Acid Derived from a Marine Sponge" @default.
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- W2043082642 doi "https://doi.org/10.1002/cbic.200700498" @default.
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