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- W2043082862 abstract "It is almost40 years since Haldane1 proposed that high frequencies of thalassaemia and other hoemoglobinopathies might result because these genetic disorders conferred some protection against malaria In the intervening years convincing clinical, epidemiological2 and in vitro data3 have been produced to support this ‘malaria hypothesis’ for haemoglobin S. However, for the numerous other genetic disorders of haemoglobin that are suspected to have been selected in this way it has been much more dif, icult to provide cleorcut evidence4. For excmple, in the case of β-thalassaemia some5 but not all epidemiological studies support the hypothesis, while in vitro studies have failed to demonstrate any impairment of either invasion or growth of P. falciparum in affected red cells under physiological conditions3." @default.
- W2043082862 created "2016-06-24" @default.
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- W2043082862 date "1987-03-01" @default.
- W2043082862 modified "2023-09-25" @default.
- W2043082862 title "Haemoglobinopathies and malaria: New approaches to an old hypothesis" @default.
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- W2043082862 doi "https://doi.org/10.1016/0169-4758(87)90164-5" @default.
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