FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043090363> ?p ?o ?g. }

• W2043090363 endingPage "1154" @default.
• W2043090363 startingPage "1145" @default.
• W2043090363 abstract "Glaucoma afflicts millions of people worldwide and is a major cause of blindness. The risk to develop glaucoma is enhanced by increases in IOP, which result from deranged flow of aqueous humor. Aqueous humor is a fluid located in the front of the eye that gives the eye its buoyancy and supplies nutrients to other eye tissues. Aqueous humor is secreted by a tissue called ciliary processes and exits the eye via two tissues; the trabecular meshwork (TM) and Schlemm’s canal. Because the spaces through which the fluid flows get smaller as the TM joins the area of the Schlemm’s canal, there is resistance to aqueous humor outflow and this resistance creates IOP. There is a correlation between changes in TM and Schlemm’s canal cell volume and rates of aqueous humor outflow; agents that decrease TM and Schlemm’s canal cell volume, increase the rate of aqueous humor outflow, thus decreasing IOP. IOP is regulated by guanylate cyclase activators as shown in humans, rabbits and monkeys. There are two distinct groups of guanylate cyclases, membrane guanylate cyclase and soluble guanylate cyclase (sGC); activation of both have been shown to decrease IOP. Members of the membrane guanylate cyclase family of receptors bind to peptide ligands, while the sGC responds to gases (such as NO and CO2) and compounds (such as YC1, [3-(5’-hydroxymethyl-2’furyl)-1-benzyl indazole), a benzyl indazole derivative, and BAY-58-2667); activation of either results in formation of cyclic GMP (cGMP) and activation of protein kinase G (PKG) and subsequent phosphorylation of target proteins, including the high conductance calcium activated potassium channel (BKca channel). While activators of both membrane guanylate cyclase and sGC have the ability to lower IOP, the IOP lowering effects of sGC are noteworthy because sGC activators can be topically applied to the eye to achieve an effect. We have demonstrated that activators of sGC increase the rate at which aqueous humor exits the eye in a time course that correlates with the time course for sGC-induced decreases in TM and Schlemm’s canal cell volume. Additionally, sGC-induced decrease in cell volume is accompanied by both K+ and Cl- efflux induced by activation of K+ and Cl- channels, including the BKca channel and/or K+Cl- symport. This suggests that parallel K+Cl- efflux, and resultant H2O efflux result in decreases in cell volume. These observations suggest a functional role for sGC activators, and suggest that the sGC/cGMP/PKG systems are potential therapeutic targets in the treatment of glaucoma." @default.
• W2043090363 created "2016-06-24" @default.
• W2043090363 creator A5060766341 @default.
• W2043090363 date "2011-01-01" @default.
• W2043090363 modified "2023-10-16" @default.
• W2043090363 title "Guanylate Cyclase Activators, Cell Volume Changes and IOP Reduction" @default.
• W2043090363 cites W1497834055 @default.
• W2043090363 cites W1509418264 @default.
• W2043090363 cites W1555733423 @default.
• W2043090363 cites W1566921440 @default.
• W2043090363 cites W1602445963 @default.
• W2043090363 cites W1821918060 @default.
• W2043090363 cites W1964141267 @default.
• W2043090363 cites W1964409706 @default.
• W2043090363 cites W1965021019 @default.
• W2043090363 cites W1967964182 @default.
• W2043090363 cites W1972476134 @default.
• W2043090363 cites W1973235785 @default.
• W2043090363 cites W1979262434 @default.
• W2043090363 cites W1982905481 @default.
• W2043090363 cites W1983742520 @default.
• W2043090363 cites W1987524416 @default.
• W2043090363 cites W1989695520 @default.
• W2043090363 cites W1989738839 @default.
• W2043090363 cites W1991441283 @default.
• W2043090363 cites W1991870376 @default.
• W2043090363 cites W1992526945 @default.
• W2043090363 cites W1994480994 @default.
• W2043090363 cites W1997272952 @default.
• W2043090363 cites W2003913161 @default.
• W2043090363 cites W2007785010 @default.
• W2043090363 cites W2007937948 @default.
• W2043090363 cites W2010862810 @default.
• W2043090363 cites W2013638901 @default.
• W2043090363 cites W2017565442 @default.
• W2043090363 cites W2028046930 @default.
• W2043090363 cites W2029270738 @default.
• W2043090363 cites W2030977438 @default.
• W2043090363 cites W2030994453 @default.
• W2043090363 cites W2036115790 @default.
• W2043090363 cites W2045076976 @default.
• W2043090363 cites W2050860348 @default.
• W2043090363 cites W2051605684 @default.
• W2043090363 cites W2054036613 @default.
• W2043090363 cites W2057554731 @default.
• W2043090363 cites W2058434113 @default.
• W2043090363 cites W2064382224 @default.
• W2043090363 cites W2072855916 @default.
• W2043090363 cites W2076257661 @default.
• W2043090363 cites W2079202995 @default.
• W2043090363 cites W2080512195 @default.
• W2043090363 cites W2080999686 @default.
• W2043090363 cites W2083336195 @default.
• W2043090363 cites W2090405680 @default.
• W2043090363 cites W2092839123 @default.
• W2043090363 cites W2099781087 @default.
• W2043090363 cites W2106828503 @default.
• W2043090363 cites W2109835398 @default.
• W2043090363 cites W2113691971 @default.
• W2043090363 cites W2114061768 @default.
• W2043090363 cites W2120711134 @default.
• W2043090363 cites W2125753558 @default.
• W2043090363 cites W2134184057 @default.
• W2043090363 cites W2140594570 @default.
• W2043090363 cites W2149205384 @default.
• W2043090363 cites W2156878508 @default.
• W2043090363 cites W2159639769 @default.
• W2043090363 cites W2160292547 @default.
• W2043090363 cites W2256724151 @default.
• W2043090363 cites W2322375502 @default.
• W2043090363 cites W2337680681 @default.
• W2043090363 cites W2467657054 @default.
• W2043090363 cites W4252375953 @default.
• W2043090363 cites W4254304954 @default.
• W2043090363 doi "https://doi.org/10.1159/000335866" @default.
• W2043090363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22179003" @default.
• W2043090363 hasPublicationYear "2011" @default.
• W2043090363 type Work @default.
• W2043090363 sameAs 2043090363 @default.
• W2043090363 citedByCount "25" @default.
• W2043090363 countsByYear W20430903632012 @default.
• W2043090363 countsByYear W20430903632013 @default.
• W2043090363 countsByYear W20430903632015 @default.
• W2043090363 countsByYear W20430903632016 @default.
• W2043090363 countsByYear W20430903632017 @default.
• W2043090363 countsByYear W20430903632018 @default.
• W2043090363 countsByYear W20430903632020 @default.
• W2043090363 countsByYear W20430903632021 @default.
• W2043090363 countsByYear W20430903632022 @default.
• W2043090363 crossrefType "journal-article" @default.
• W2043090363 hasAuthorship W2043090363A5060766341 @default.
• W2043090363 hasBestOaLocation W20430903631 @default.
• W2043090363 hasConcept C118487528 @default.
• W2043090363 hasConcept C12554922 @default.
• W2043090363 hasConcept C126322002 @default.
• W2043090363 hasConcept C170493617 @default.
• W2043090363 hasConcept C185592680 @default.
• W2043090363 hasConcept C2778527774 @default.

• next