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- W2043093524 abstract "Non-invasive convenient biomarkers of brain function are essential for drug development and as diagnostic aids to primary care physicians and neurologists. Static imaging (MRI/PET/SPECT) and fluid based (blood and CSF) biomarkers don't typically capture inherent brain physiology and dynamic processes. The current study introduces a portable activated EEG medical device for the physiological assessment of brain health and responsiveness to therapy. Advanced wireless electroencephalography hardware has enabled BCI to develop a novel activated EEG system (MindScope™). This system conveniently assesses brain responsiveness to activation of sensory circuits by various stimuli as well as cognitive tasks. EEG is recorded at position Fp1 (10-20 electrode placement system) with a Bluetooth enabled telemetric headset. Proprietary BCI software (BCiLab™ Clinic) both (i) activates brain circuits (beyond resting state conditions) with auditory stimulation, photic stimulation and/or cognitive tasks from the CogState computer cognition battery or the Paced Arithmetic Serial Assessment Test (PASAT) while (ii) simultaneously recording the raw EEG data and subject responses for post-acquisition spectral analysis. Bench top assessment of the hardware/software system was conducted by BCI under a US Army Phase 1 SBIR contract. After IRB approval, preliminary assessment of MindScope™ was conducted in subjects (N = 10 in each of 20, 40, 60, 70, 80 years of age) and mild to moderate dementia patients, as assessed by Mini-mental State Exam. Analytical testing showed excellent signal to noise ratio of greater than 20 db as well as low intra subject variation. Preliminary studies with CNS active compounds have shown statistically significant differences pre versus post compound administration. Preliminary data in humans from the Palm Drive Hospital Aging study and the Alzheimer study will be presented. A physiologically focused battery of tasks to functionally activate EEG is able to probe elements of brain circuits not presently assessed with standard resting state quantitative EEG. The MindScope offers a convenient and novel alternative to rapidly, portably and non-invasively assess brain health and function with no requirement for technical EEG training. Further work is required to develop the necessary activated EEG signatures to map the brain for its physiological defects." @default.
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- W2043093524 date "2011-07-01" @default.
- W2043093524 modified "2023-10-18" @default.
- W2043093524 title "P1‐112: A brain computer interface to detect Alzheimer's disease" @default.
- W2043093524 doi "https://doi.org/10.1016/j.jalz.2011.05.391" @default.
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