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- W2043105092 endingPage "1231" @default.
- W2043105092 startingPage "1195" @default.
- W2043105092 abstract "The ErbB/EGFR/HER family of kinases consists of four homologous receptor tyrosine kinases which are important regulatory elements in many cellular processes, including cell proliferation, differentiation, and migration. Somatic mutations in, or over-expression of, the ErbB family is found in many cancers and is correlated with a poor prognosis; particularly, clinically identified mutations found in non-small-cell lung cancer (NSCLC) of ErbB1 have been shown to increase its basal kinase activity and patients carrying these mutations respond remarkably to the small tyrosine kinase inhibitor gefitinib. Here, we analyze the potential effects of the currently catalogued clinically identified mutations in the ErbB family kinase domains on the molecular mechanisms of kinase activation. Recently, we identified conserved networks of hydrophilic and hydrophobic interactions characteristic to the active and inactive conformation, respectively. Here, we show that the clinically identified mutants influence the kinase activity in distinctive fashion by affecting the characteristic interaction networks." @default.
- W2043105092 created "2016-06-24" @default.
- W2043105092 creator A5012147644 @default.
- W2043105092 creator A5037007496 @default.
- W2043105092 creator A5041698645 @default.
- W2043105092 date "2011-03-10" @default.
- W2043105092 modified "2023-10-11" @default.
- W2043105092 title "Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases" @default.
- W2043105092 cites W1520077451 @default.
- W2043105092 cites W1526010137 @default.
- W2043105092 cites W1592402132 @default.
- W2043105092 cites W1840850597 @default.
- W2043105092 cites W1870193477 @default.
- W2043105092 cites W1937853139 @default.
- W2043105092 cites W1964619587 @default.
- W2043105092 cites W1965950769 @default.
- W2043105092 cites W1966311581 @default.
- W2043105092 cites W1966658428 @default.
- W2043105092 cites W1967628621 @default.
- W2043105092 cites W1969918683 @default.
- W2043105092 cites W1971056717 @default.
- W2043105092 cites W1972648135 @default.
- W2043105092 cites W1973756075 @default.
- W2043105092 cites W1974647057 @default.
- W2043105092 cites W1976284448 @default.
- W2043105092 cites W1979056373 @default.
- W2043105092 cites W1979332174 @default.
- W2043105092 cites W1986538148 @default.
- W2043105092 cites W1988588903 @default.
- W2043105092 cites W1988656539 @default.
- W2043105092 cites W1990030298 @default.
- W2043105092 cites W1990774346 @default.
- W2043105092 cites W1991335138 @default.
- W2043105092 cites W1991874467 @default.
- W2043105092 cites W1993804787 @default.
- W2043105092 cites W1994105285 @default.
- W2043105092 cites W1994485012 @default.
- W2043105092 cites W1995242599 @default.
- W2043105092 cites W1995675538 @default.
- W2043105092 cites W1996737475 @default.
- W2043105092 cites W1998971866 @default.
- W2043105092 cites W2000390423 @default.
- W2043105092 cites W2001620484 @default.
- W2043105092 cites W2001859978 @default.
- W2043105092 cites W2004834404 @default.
- W2043105092 cites W2010978319 @default.
- W2043105092 cites W2012634952 @default.
- W2043105092 cites W2016010426 @default.
- W2043105092 cites W2016568386 @default.
- W2043105092 cites W2016710415 @default.
- W2043105092 cites W2017081079 @default.
- W2043105092 cites W2018169163 @default.
- W2043105092 cites W2018204057 @default.
- W2043105092 cites W2019658525 @default.
- W2043105092 cites W2022354436 @default.
- W2043105092 cites W2023012881 @default.
- W2043105092 cites W2024510824 @default.
- W2043105092 cites W2025351920 @default.
- W2043105092 cites W2027359959 @default.
- W2043105092 cites W2028415754 @default.
- W2043105092 cites W2031575519 @default.
- W2043105092 cites W2033488181 @default.
- W2043105092 cites W2034602668 @default.
- W2043105092 cites W2035282066 @default.
- W2043105092 cites W2036740994 @default.
- W2043105092 cites W2039233888 @default.
- W2043105092 cites W2041415161 @default.
- W2043105092 cites W2043696829 @default.
- W2043105092 cites W2045709340 @default.
- W2043105092 cites W2046259235 @default.
- W2043105092 cites W2047797038 @default.
- W2043105092 cites W2048993739 @default.
- W2043105092 cites W2049184213 @default.
- W2043105092 cites W2049449785 @default.
- W2043105092 cites W2049507332 @default.
- W2043105092 cites W2050046701 @default.
- W2043105092 cites W2052420692 @default.
- W2043105092 cites W2053521827 @default.
- W2043105092 cites W2058620780 @default.
- W2043105092 cites W2058862385 @default.
- W2043105092 cites W2059736253 @default.
- W2043105092 cites W2060275730 @default.
- W2043105092 cites W2062855968 @default.
- W2043105092 cites W2065285374 @default.
- W2043105092 cites W2067083902 @default.
- W2043105092 cites W2068244265 @default.
- W2043105092 cites W2068864761 @default.
- W2043105092 cites W2069526613 @default.
- W2043105092 cites W2075161553 @default.
- W2043105092 cites W2075264134 @default.
- W2043105092 cites W2076677849 @default.
- W2043105092 cites W2076718022 @default.
- W2043105092 cites W2080251370 @default.
- W2043105092 cites W2081070994 @default.
- W2043105092 cites W2082590470 @default.
- W2043105092 cites W2082592896 @default.
- W2043105092 cites W2083547960 @default.
- W2043105092 cites W2084200464 @default.