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• W2043105877 abstract "The bioassay-guided purification of an n-hexane extract from the leaves of Piper hostmannianum var. berbicense led to the isolation of four monoterpene or prenyl-substituted dihydrochalcones (1a, 1b, 2, 3) as well as the known compounds 2′,6′-dihydroxy-4′-methoxydihydrochalcone (4), linderatone (5), strobopinin (6), adunctin E (7) and (−)-methyllinderatin (8). Their structures were established on the basis of NMR and X-ray analysis. (−)-Methyllinderatin, linderatone and 2′,6′-dihydroxy-4′-methoxydihydrochalcone exhibited the most potent antiplasmodial activity with IC50 values of 5.64, 10.33 and 12.69 μM, respectively against both chloroquine-sensitive and resistant strains of Plasmodium falciparum (F32, FcB1). The activity of (−)-methyllinderatin was confirmed in vivo against Plasmodium vinckei petteri in mice (80% of reduction of parasitemia) at a dose of 20 mg/kg/day." @default.
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• W2043105877 date "2007-05-01" @default.
• W2043105877 modified "2023-10-16" @default.
• W2043105877 title "Activity-guided isolation of antiplasmodial dihydrochalcones and flavanones from Piper hostmannianum var. berbicense" @default.
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• W2043105877 doi "https://doi.org/10.1016/j.phytochem.2007.02.006" @default.
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