Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043107072> ?p ?o ?g. }
- W2043107072 endingPage "730" @default.
- W2043107072 startingPage "722" @default.
- W2043107072 abstract "Anti-Ro antibodies are found in a large proportion of patients with systemic lupus erythematosus and primary Sjögren's syndrome. These antibodies also characterize neonatal lupus, subacute cutaneous lupus erythematosus, and vasculitis associated with Sjögren's syndrome and rheumatoid arthritis. Anti-Ro-positive sera may contain either or both of 2 sets of antibodies, recognizing either a 60-kd or a 52-kd polypeptide component of the Ro particle. We found in this study that the immune response to the 60-kd Ro antigen is heterogeneous. Some sera specifically recognize the native Ro antigen but fail to bind the corresponding denatured polypeptides. In addition, after immunodepletion using the denatured 60-kd Ro polypeptide, all anti-Ro-positive sera tested still contained high titers of antibodies recognizing conformational determinants on the Ro antigen. The frequent immunodominance of anti-Ro antibodies targeted to conformational determinants suggests that native autoantigens may directly drive the autoimmune response." @default.
- W2043107072 created "2016-06-24" @default.
- W2043107072 creator A5023988126 @default.
- W2043107072 creator A5024757072 @default.
- W2043107072 creator A5064607517 @default.
- W2043107072 creator A5066279389 @default.
- W2043107072 date "1991-06-01" @default.
- W2043107072 modified "2023-09-25" @default.
- W2043107072 title "Sera from patients with autoimmune disease recognize conformational determinants on the 60-kd ro/ss-a protein" @default.
- W2043107072 cites W1582424095 @default.
- W2043107072 cites W160997634 @default.
- W2043107072 cites W1871134247 @default.
- W2043107072 cites W1944505228 @default.
- W2043107072 cites W1965254399 @default.
- W2043107072 cites W1969108300 @default.
- W2043107072 cites W1982764945 @default.
- W2043107072 cites W1983420108 @default.
- W2043107072 cites W1987524809 @default.
- W2043107072 cites W1988994410 @default.
- W2043107072 cites W1991406988 @default.
- W2043107072 cites W2006964904 @default.
- W2043107072 cites W2012284676 @default.
- W2043107072 cites W2012552244 @default.
- W2043107072 cites W2022177986 @default.
- W2043107072 cites W2026102856 @default.
- W2043107072 cites W2028949050 @default.
- W2043107072 cites W2035449296 @default.
- W2043107072 cites W2035653882 @default.
- W2043107072 cites W2048375132 @default.
- W2043107072 cites W2049572705 @default.
- W2043107072 cites W2055306792 @default.
- W2043107072 cites W2063813207 @default.
- W2043107072 cites W2072946918 @default.
- W2043107072 cites W2077938714 @default.
- W2043107072 cites W2081018711 @default.
- W2043107072 cites W2089294704 @default.
- W2043107072 cites W2100837269 @default.
- W2043107072 cites W2101108802 @default.
- W2043107072 cites W2111301002 @default.
- W2043107072 cites W2125098212 @default.
- W2043107072 cites W2136701955 @default.
- W2043107072 cites W2327871226 @default.
- W2043107072 cites W2338721595 @default.
- W2043107072 cites W2410821248 @default.
- W2043107072 cites W4245315362 @default.
- W2043107072 doi "https://doi.org/10.1002/art.1780340613" @default.
- W2043107072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1711323" @default.
- W2043107072 hasPublicationYear "1991" @default.
- W2043107072 type Work @default.
- W2043107072 sameAs 2043107072 @default.
- W2043107072 citedByCount "110" @default.
- W2043107072 countsByYear W20431070722012 @default.
- W2043107072 countsByYear W20431070722013 @default.
- W2043107072 countsByYear W20431070722016 @default.
- W2043107072 countsByYear W20431070722017 @default.
- W2043107072 countsByYear W20431070722018 @default.
- W2043107072 countsByYear W20431070722021 @default.
- W2043107072 countsByYear W20431070722022 @default.
- W2043107072 crossrefType "journal-article" @default.
- W2043107072 hasAuthorship W2043107072A5023988126 @default.
- W2043107072 hasAuthorship W2043107072A5024757072 @default.
- W2043107072 hasAuthorship W2043107072A5064607517 @default.
- W2043107072 hasAuthorship W2043107072A5066279389 @default.
- W2043107072 hasConcept C142724271 @default.
- W2043107072 hasConcept C147483822 @default.
- W2043107072 hasConcept C159654299 @default.
- W2043107072 hasConcept C195616568 @default.
- W2043107072 hasConcept C203014093 @default.
- W2043107072 hasConcept C2776525413 @default.
- W2043107072 hasConcept C2776912625 @default.
- W2043107072 hasConcept C2777575956 @default.
- W2043107072 hasConcept C2779075594 @default.
- W2043107072 hasConcept C2779134260 @default.
- W2043107072 hasConcept C32611913 @default.
- W2043107072 hasConcept C71924100 @default.
- W2043107072 hasConcept C8891405 @default.
- W2043107072 hasConceptScore W2043107072C142724271 @default.
- W2043107072 hasConceptScore W2043107072C147483822 @default.
- W2043107072 hasConceptScore W2043107072C159654299 @default.
- W2043107072 hasConceptScore W2043107072C195616568 @default.
- W2043107072 hasConceptScore W2043107072C203014093 @default.
- W2043107072 hasConceptScore W2043107072C2776525413 @default.
- W2043107072 hasConceptScore W2043107072C2776912625 @default.
- W2043107072 hasConceptScore W2043107072C2777575956 @default.
- W2043107072 hasConceptScore W2043107072C2779075594 @default.
- W2043107072 hasConceptScore W2043107072C2779134260 @default.
- W2043107072 hasConceptScore W2043107072C32611913 @default.
- W2043107072 hasConceptScore W2043107072C71924100 @default.
- W2043107072 hasConceptScore W2043107072C8891405 @default.
- W2043107072 hasIssue "6" @default.
- W2043107072 hasLocation W20431070721 @default.
- W2043107072 hasLocation W20431070722 @default.
- W2043107072 hasOpenAccess W2043107072 @default.
- W2043107072 hasPrimaryLocation W20431070721 @default.
- W2043107072 hasRelatedWork W1484759019 @default.
- W2043107072 hasRelatedWork W1539989077 @default.
- W2043107072 hasRelatedWork W1845358311 @default.
- W2043107072 hasRelatedWork W2018825951 @default.