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- W2043113025 abstract "Objective: To explore the effects of ghrelin on disturbed myocardial energy metabolism during chronic heart failure (CHF). Methods: Rats were subcutaneously injected with isoproterenol (ISO) for 10 days and with or without ghrelin for another 10 days. Enzyme immunoassay was to measure ghrelin concentrations. The myocardial mRNA levels of ghrelin/growth hormone secretatogue receptor (GHS-R), and monocarboxylate transporter-1 (MCT1) were determined by RT-PCR, and their protein expressions by western blot and immunohistochemistry, respectively. Results: Compared with the control group, ISO-treated rats showed suppressed cardiac function with high ghrelin/GHS-R expressions. These rats also showed decreases in food consumption and weight. The decreased levels of plasma glucose and myocardial glycogen, but the high lactate in blood and myocardium showed myocardial metabolic disturbance. Compared with the group given ISO alone, the rats with ghrelin (20 and 100 μg/kg/day) have improved cardiac dysfunction and increased food intake by 13.5% and 14.2% (both P<0.01), and rate of weight gain by 95% (P<0.05) and 1.71-fold (P<0.01), respectively. The plasma glucose was increased by 49.7% and 50.8% (both P<0.01), and myocardial glycogen, by 40.5% and 51.7% (both P<0.01), but blood lactate decreased by 1.56- and 1.96-fold (both P<0.01), and myocardial lactate by 32.1% and 48.7% (both P<0.05), respectively. Their MCT1 mRNA and protein expressions increased. Conclusion: The myocardial ghrelin/GHS-R pathway can be upregulated during CHF. The ghrelin can attenuate cardiac dysfunction and energy metabolic disturbance in CHF rats. Ghrelin might be a new therapeutic approach to cachexia in CHF." @default.
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- W2043113025 date "2011-10-01" @default.
- W2043113025 modified "2023-09-23" @default.
- W2043113025 title "Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol" @default.
- W2043113025 doi "https://doi.org/10.1016/j.ijcard.2011.08.649" @default.
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