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• W2043132624 abstract "Large excitatory synapses in the auditory system, such as the calyx of Held, faithfully transmit trains of action potentials up to a frequency of a few hundred hertz, and these synapses are thought to display a limited repertoire of synaptic plasticity. Here, we show that brief trains of 100 Hz stimulation induce posttetanic potentiation (PTP) of transmitter release at the calyx of Held. In young rats [postnatal day 4 (P4) to P6], PTP could be induced with shorter 100 Hz trains compared with older age groups (P8-P10 and P12-P14), but the maximal amount of PTP was similar, with 200% of control EPSC amplitude. The size of the readily releasable pool of vesicles was not increased significantly during PTP. Bath application of the membrane-permeable Ca2+ chelator EGTA-AM suppressed PTP, indicating a role for presynaptic Ca2+ in PTP at the calyx of Held. Presynaptic Ca2+ imaging showed that the intracellular Ca2+ concentration, [Ca2+]i, was increased by 40-120 nM at the peak of PTP, and this residual [Ca2+]i decayed in parallel with PTP, with time constants in the range of 10-60 s. During whole-cell recording of the presynaptic calyx of Held, PTP was absent, and the decay of residual [Ca2+]i was strongly accelerated. The data show that the calyx of Held expresses a mechanism of transmitter release potentiation in which a small, sustained elevation of basal [Ca2+]i increases the transmitter release probability after trains of high-frequency stimulation." @default.
• W2043132624 created "2016-06-24" @default.
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• W2043132624 creator A5031795088 @default.
• W2043132624 creator A5053378337 @default.
• W2043132624 date "2005-05-25" @default.
• W2043132624 modified "2023-09-25" @default.
• W2043132624 title "Presynaptic Ca²⁺Requirements and Developmental Regulation of Posttetanic Potentiation at the Calyx of Held" @default.
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• W2043132624 doi "https://doi.org/10.1523/jneurosci.1295-05.2005" @default.
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