FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043136696> ?p ?o ?g. }

• W2043136696 endingPage "4054" @default.
• W2043136696 startingPage "4047" @default.
• W2043136696 abstract "In response to DNA damage and replication blocks, cells activate pathways that arrest the cell cycle and induce the transcription of genes that facilitate repair. In mammals, ATM (ataxia telangiectasia mutated) kinase together with other checkpoint kinases are important components in this response. We have cloned the rat and human homologs of Saccharomyces cerevisiae Rad 53 and Schizosaccharomyces pombe Cds1, called checkpoint kinase 2 (chk2). Complementation studies suggest that Chk2 can partially replace the function of the defective checkpoint kinase in the Cds1 deficient yeast strain. Chk2 was phosphorylated and activated in response to DNA damage in an ATM dependent manner. Its activation in response to replication blocks by hydroxyurea (HU) treatment, however, was independent of ATM. Using mass spectrometry, we found that, similar to Chk1, Chk2 can phosphorylate serine 216 in Cdc25C, a site known to be involved in negative regulation of Cdc25C. These results suggest that Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Activation of Chk2 might not only delay mitotic entry, but also increase the capacity of cultured cells to survive after treatment with gamma-radiation or with the topoisomerase-I inhibitor topotecan." @default.
• W2043136696 created "2016-06-24" @default.
• W2043136696 creator A5012152790 @default.
• W2043136696 creator A5012496556 @default.
• W2043136696 creator A5029807955 @default.
• W2043136696 creator A5030517432 @default.
• W2043136696 creator A5033585350 @default.
• W2043136696 creator A5033951135 @default.
• W2043136696 creator A5036255260 @default.
• W2043136696 creator A5036331253 @default.
• W2043136696 creator A5040214723 @default.
• W2043136696 creator A5040334133 @default.
• W2043136696 creator A5041975716 @default.
• W2043136696 creator A5048918848 @default.
• W2043136696 creator A5077781711 @default.
• W2043136696 creator A5079573168 @default.
• W2043136696 creator A5081780524 @default.
• W2043136696 creator A5090790616 @default.
• W2043136696 date "1999-07-15" @default.
• W2043136696 modified "2023-10-10" @default.
• W2043136696 title "Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway" @default.
• W2043136696 cites W1490400638 @default.
• W2043136696 cites W1566625041 @default.
• W2043136696 cites W1597133026 @default.
• W2043136696 cites W1607596288 @default.
• W2043136696 cites W1677118171 @default.
• W2043136696 cites W1971040573 @default.
• W2043136696 cites W1974425687 @default.
• W2043136696 cites W1981987977 @default.
• W2043136696 cites W1986179131 @default.
• W2043136696 cites W1988876917 @default.
• W2043136696 cites W1994909028 @default.
• W2043136696 cites W1999479097 @default.
• W2043136696 cites W2004008931 @default.
• W2043136696 cites W2011287943 @default.
• W2043136696 cites W2020209954 @default.
• W2043136696 cites W2033950216 @default.
• W2043136696 cites W2034306661 @default.
• W2043136696 cites W2037728125 @default.
• W2043136696 cites W2046589688 @default.
• W2043136696 cites W2049508647 @default.
• W2043136696 cites W2062232773 @default.
• W2043136696 cites W2075045273 @default.
• W2043136696 cites W2076314401 @default.
• W2043136696 cites W2078242581 @default.
• W2043136696 cites W2083456378 @default.
• W2043136696 cites W2086430589 @default.
• W2043136696 cites W2090601888 @default.
• W2043136696 cites W2091782725 @default.
• W2043136696 cites W2102433010 @default.
• W2043136696 cites W2105592350 @default.
• W2043136696 cites W2110629065 @default.
• W2043136696 cites W2110740129 @default.
• W2043136696 cites W2113439921 @default.
• W2043136696 cites W2128994729 @default.
• W2043136696 cites W2150688223 @default.
• W2043136696 cites W2159168998 @default.
• W2043136696 doi "https://doi.org/10.1038/sj.onc.1202925" @default.
• W2043136696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10435585" @default.
• W2043136696 hasPublicationYear "1999" @default.
• W2043136696 type Work @default.
• W2043136696 sameAs 2043136696 @default.
• W2043136696 citedByCount "407" @default.
• W2043136696 countsByYear W20431366962012 @default.
• W2043136696 countsByYear W20431366962013 @default.
• W2043136696 countsByYear W20431366962014 @default.
• W2043136696 countsByYear W20431366962015 @default.
• W2043136696 countsByYear W20431366962016 @default.
• W2043136696 countsByYear W20431366962017 @default.
• W2043136696 countsByYear W20431366962018 @default.
• W2043136696 countsByYear W20431366962019 @default.
• W2043136696 countsByYear W20431366962020 @default.
• W2043136696 countsByYear W20431366962021 @default.
• W2043136696 countsByYear W20431366962022 @default.
• W2043136696 countsByYear W20431366962023 @default.
• W2043136696 crossrefType "journal-article" @default.
• W2043136696 hasAuthorship W2043136696A5012152790 @default.
• W2043136696 hasAuthorship W2043136696A5012496556 @default.
• W2043136696 hasAuthorship W2043136696A5029807955 @default.
• W2043136696 hasAuthorship W2043136696A5030517432 @default.
• W2043136696 hasAuthorship W2043136696A5033585350 @default.
• W2043136696 hasAuthorship W2043136696A5033951135 @default.
• W2043136696 hasAuthorship W2043136696A5036255260 @default.
• W2043136696 hasAuthorship W2043136696A5036331253 @default.
• W2043136696 hasAuthorship W2043136696A5040214723 @default.
• W2043136696 hasAuthorship W2043136696A5040334133 @default.
• W2043136696 hasAuthorship W2043136696A5041975716 @default.
• W2043136696 hasAuthorship W2043136696A5048918848 @default.
• W2043136696 hasAuthorship W2043136696A5077781711 @default.
• W2043136696 hasAuthorship W2043136696A5079573168 @default.
• W2043136696 hasAuthorship W2043136696A5081780524 @default.
• W2043136696 hasAuthorship W2043136696A5090790616 @default.
• W2043136696 hasBestOaLocation W20431366961 @default.
• W2043136696 hasConcept C104317684 @default.
• W2043136696 hasConcept C105696609 @default.
• W2043136696 hasConcept C134935766 @default.
• W2043136696 hasConcept C143425029 @default.
• W2043136696 hasConcept C184235292 @default.

• next