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- W204314577 abstract "Although the intensity of the biological response to experimentally administered corticoids is known to vary widely, the relationship of the route by which a hormone is administered to its metabolism and physiological action is poorly understood. Porter and Silber (1) have described the varying glycogenic activity of cortisone, hydrocortisone, and their acetates after subcutaneous and intramuscular administration to rats. Bradlow et al. (2) reported different patterns of tritium excretion after intravenous, intramuscular, or intraperitoneal injection of cortisone-T in mice. However, Bocklage and coworkers (3) found essentially no difference in the amounts of Cl4 excreted or in pathways of excretion after intramuscular or intragastric administration of cortisone-4-Cl4 acetate to rats. Wyngaarden et al. (4, 5) found the physiological disposition of radioactivity after subcutaneous injection of hydrocortisone-4-Cl4 in rats to be the same as that reported for cortisone-4-Cl4 acetate (3) and ll-dehydrocorticosterone21-Cl4 (6). Since the liver is the major site of inactivation of the glucocorticoids in rodents (7-15)) the rate of absorption and of transport of these compounds to that organ should affect the amount of metabolic activity elicited. Only after hydrocortisone-4-Cl4 of sufficient specific activity (4 PC. per mg.) became available could relatively physiological quantities (50 7) of this hormone be given to animals in order to determine the metabolic pathways. These studies were initiated to ascertain whether the route of administration of the radiosteroid affects its metabolism. The intravenous, intramuscular, sublingual, and intragastric routes were chosen because these are the ones usually available for therapeusis and because they had not been studied at the same dose level before. Reabsorption of the biliary radiometabolites was investigated in animals with bile fistulas to learn whether enterohepatic circulation is a factor in the metabolism of radiohy-" @default.
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- W204314577 date "1957-08-01" @default.
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- W204314577 title "ABSORPTION AND METABOLISM OF HYDROCORTISONE-4-C14" @default.
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- W204314577 doi "https://doi.org/10.1016/s0021-9258(18)70784-9" @default.
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