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- W2043149445 abstract "Previous studies have revealed the existence of two separate phases in the glucose-stimulated insulin release. Exposure of microdissected mouse islets to mannoheptulose or epinephrine effectively inhibited both the initial transient release and the second persistent phase of insulin secretion. These results suggest that metabolism of glucose is a prerequisite for both phases of insulin release. The current view of mannoheptulose as an inhibitor of the β-cell phosphorylation of glucose was corroborated by the observation that this drug prevented the increase of fructose-1,6-diphosphate normally observed with increasing glucose levels." @default.
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- W2043149445 title "Effect of epinephrine and mannoheptulose on early and late phases of glucose-stimulated insulin release" @default.
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- W2043149445 doi "https://doi.org/10.1016/0026-0495(70)90018-1" @default.
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