Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043156538> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2043156538 endingPage "S46" @default.
- W2043156538 startingPage "S46" @default.
- W2043156538 abstract "Naproxen belongs to commonly used NSAIDs associated with less cardiovascular toxicity than selective COX-2 inhibitors and other NSAIDs but its use is limited due to serious gastrointestinal (GI)-tract adverse effects. Novel H2S-releasing derivative of naproxen (ATB-346) was shown to inhibit COX-1 and prostaglandins (PGs) generation without causing mucosal damage unlike parent drug but whether ATB-346 can affect stress-induced gastric damage remains unknown. We compared ATB-346 vs naproxen and celecoxib and determined the role of reactive oxygen species and cytokines in the action of these NSAIDs against water immersion restraint stress (WRS)-induced gastric lesions in rats. WRS exposed animals were pretreated with (1) naproxen, (2) ATB-346 (0.5–40 m/kg i.g.), and (3) celecoxib (10 mg/kg i.g.) with or without ODQ (5 mg/kg i.p.), selective guanylate cyclase inhibitor or BCA (10 mg/kg i.p.), the inhibitor of H2S-synthesizing enzyme CSE. The number of gastric lesions was assessed by planimetry, the gastric blood flow (GBF) by H2-gas clearance technique, the malonyldialdehyde (MDA) concentration, MPO and PGE2 generation, the plasma level of IL-1beta and TNF-alpha and the expression of SOD and glutathione peroxidase (GPx) were determined by ELISA and RT-PCR. Pretreatment with ATB-346 dose-dependently reduced WRS-induced gastric lesions; the dose inhibiting these lesions by 50% being 29 mg/kg, caused significant rise in GBF and fall in MPO and MDA content. These effects of ATB-346 were reversed by cotreatment with ODQ but not BCA (p" @default.
- W2043156538 created "2016-06-24" @default.
- W2043156538 creator A5016535870 @default.
- W2043156538 creator A5022479905 @default.
- W2043156538 creator A5023067950 @default.
- W2043156538 creator A5024846906 @default.
- W2043156538 creator A5026040870 @default.
- W2043156538 creator A5027937626 @default.
- W2043156538 creator A5045493260 @default.
- W2043156538 creator A5090892875 @default.
- W2043156538 date "2014-05-01" @default.
- W2043156538 modified "2023-10-18" @default.
- W2043156538 title "P101 Comparative study with hydrogen sulfide (H2S)-releasing derivative of naproxen ATB-346, naproxen and cyclooxygenase (COX)-2 inhibitor in the mechanisms of gastric mucosa injury induced by stress" @default.
- W2043156538 doi "https://doi.org/10.1016/j.niox.2014.03.151" @default.
- W2043156538 hasPublicationYear "2014" @default.
- W2043156538 type Work @default.
- W2043156538 sameAs 2043156538 @default.
- W2043156538 citedByCount "0" @default.
- W2043156538 crossrefType "journal-article" @default.
- W2043156538 hasAuthorship W2043156538A5016535870 @default.
- W2043156538 hasAuthorship W2043156538A5022479905 @default.
- W2043156538 hasAuthorship W2043156538A5023067950 @default.
- W2043156538 hasAuthorship W2043156538A5024846906 @default.
- W2043156538 hasAuthorship W2043156538A5026040870 @default.
- W2043156538 hasAuthorship W2043156538A5027937626 @default.
- W2043156538 hasAuthorship W2043156538A5045493260 @default.
- W2043156538 hasAuthorship W2043156538A5090892875 @default.
- W2043156538 hasConcept C126322002 @default.
- W2043156538 hasConcept C142724271 @default.
- W2043156538 hasConcept C181199279 @default.
- W2043156538 hasConcept C185592680 @default.
- W2043156538 hasConcept C203565725 @default.
- W2043156538 hasConcept C204787440 @default.
- W2043156538 hasConcept C2776151105 @default.
- W2043156538 hasConcept C2776467144 @default.
- W2043156538 hasConcept C2776914184 @default.
- W2043156538 hasConcept C2778115740 @default.
- W2043156538 hasConcept C2779422922 @default.
- W2043156538 hasConcept C2779689624 @default.
- W2043156538 hasConcept C2780073392 @default.
- W2043156538 hasConcept C2781443798 @default.
- W2043156538 hasConcept C55493867 @default.
- W2043156538 hasConcept C71924100 @default.
- W2043156538 hasConcept C98274493 @default.
- W2043156538 hasConceptScore W2043156538C126322002 @default.
- W2043156538 hasConceptScore W2043156538C142724271 @default.
- W2043156538 hasConceptScore W2043156538C181199279 @default.
- W2043156538 hasConceptScore W2043156538C185592680 @default.
- W2043156538 hasConceptScore W2043156538C203565725 @default.
- W2043156538 hasConceptScore W2043156538C204787440 @default.
- W2043156538 hasConceptScore W2043156538C2776151105 @default.
- W2043156538 hasConceptScore W2043156538C2776467144 @default.
- W2043156538 hasConceptScore W2043156538C2776914184 @default.
- W2043156538 hasConceptScore W2043156538C2778115740 @default.
- W2043156538 hasConceptScore W2043156538C2779422922 @default.
- W2043156538 hasConceptScore W2043156538C2779689624 @default.
- W2043156538 hasConceptScore W2043156538C2780073392 @default.
- W2043156538 hasConceptScore W2043156538C2781443798 @default.
- W2043156538 hasConceptScore W2043156538C55493867 @default.
- W2043156538 hasConceptScore W2043156538C71924100 @default.
- W2043156538 hasConceptScore W2043156538C98274493 @default.
- W2043156538 hasLocation W20431565381 @default.
- W2043156538 hasOpenAccess W2043156538 @default.
- W2043156538 hasPrimaryLocation W20431565381 @default.
- W2043156538 hasRelatedWork W1554167221 @default.
- W2043156538 hasRelatedWork W1982144369 @default.
- W2043156538 hasRelatedWork W1988476789 @default.
- W2043156538 hasRelatedWork W2009741906 @default.
- W2043156538 hasRelatedWork W2023887529 @default.
- W2043156538 hasRelatedWork W2027206177 @default.
- W2043156538 hasRelatedWork W2027539046 @default.
- W2043156538 hasRelatedWork W2029139439 @default.
- W2043156538 hasRelatedWork W2038035298 @default.
- W2043156538 hasRelatedWork W2049549002 @default.
- W2043156538 hasRelatedWork W2056020278 @default.
- W2043156538 hasRelatedWork W2072004058 @default.
- W2043156538 hasRelatedWork W2074917122 @default.
- W2043156538 hasRelatedWork W2085734291 @default.
- W2043156538 hasRelatedWork W2101132810 @default.
- W2043156538 hasRelatedWork W2110466642 @default.
- W2043156538 hasRelatedWork W2119671318 @default.
- W2043156538 hasRelatedWork W2351708691 @default.
- W2043156538 hasRelatedWork W2396034111 @default.
- W2043156538 hasRelatedWork W2337429451 @default.
- W2043156538 hasVolume "39" @default.
- W2043156538 isParatext "false" @default.
- W2043156538 isRetracted "false" @default.
- W2043156538 magId "2043156538" @default.
- W2043156538 workType "article" @default.