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• W2043160183 abstract "This book, described by the authors as an “introductory manual,” reviews the roles of conventional and advanced imaging and radiation treatment for the management of lymphomas. Lymphomas are relatively radiosensitive, and radiation treatment has an important role. However, most lymphomas, which have a diverse cohort of disease types and anatomical locations, are primarily treated through the use of chemotherapeutic agents. At the same time, imaging is used for diagnosis and especially staging, and image-based radiation treatment using lymphoma target volumes defined on anatomic and functional (e.g., biological) imaging is a developing technique. Thus, the presentation of image-based radiation treatment of lymphomas makes this manual a niche reference document for those clinically oriented individuals with an interest in lymphomas as well as the developing roles for radiation treatment. The premise of this manual is that “functional imaging,” that is, imaging that shows both biology and anatomy (“bioanatomic imaging”), has a growing role in (1) diagnosis, (2) staging, (3) radiation treatment, and (4) response monitoring for lymphomas. The challenging issues for lymphoma are that, while nodal regions can be identified as radiation targets, lymphomas tend to be heterogeneous with poorly defined borders that appear diffuse on anatomical as well as functional imaging. Mainly, the functional imaging presented is FDG-PET (PET/CT) and its uses in staging and treatment planning, although non-FDG-PET is mentioned. The title, “Image-Guided Radiation Therapy” is somewhat misleading, because image-based treatment of lymphoma is presented (e.g., staging, treatment planning), but image-guidance for verification of individual treatment fractions is not presented. This limitation likely agrees with the editor's statements that the book may stimulate technologies for better radiotherapy of lymphomas. In this sense, this book may be ahead of its time. Clinically oriented individuals such as residents and clinicians, and those seeking background materials on lymphomas, will find this relatively short book (10 chapters, 80 pages) of use, particularly if they are interested in lymphoma multidisciplinary treatment regimens. The editors and authors are from the Cleveland Clinic, and the material presented summarizes their treatment approaches. Anatomic (CT and MR) and functional (FDG-PET, PET/CT, and non-FDG-PET) imaging are presented, with relevance for diagnosis and staging. The authors note that uses in treatment planning and treatment response for PET imaging are still developing, including qualitative vs. quantitative PET image assessment for detection of cancer (e.g., SUV > 2.2 indicates malignancy). After a well-written chapter on FDG-PET imaging for oncology, approaches with PET imaging and radiotherapy are described for Hodgkin's, Non-Hodgkin's, orbital, primary CNS, and other lymphomas. These chapters include good clinical reviews for each lymphoma type and sometimes include example radiation treatment plans. A weakness is that, given the emphasis on functional imaging, there are relatively few images showing CT, PET, and PET/CT presentations for each type of lymphoma, although the challenges of lymphoma target definition are discussed. And, as stated earlier, IGRT content (e.g., daily, in-room imaging for treatment validation) is nonexistent. Essentially, the editors have put forward a summary to stimulate work in imaging and radiation treatment for the benefit of future lymphoma patients. In this introductory manual, the editors and authors share their imaging and radiation oncology expertise for the management of lymphomas, with hopes of encouraging new radiation approaches and multidisciplinary care for patients with this diverse disease. While imaging has its place for diagnosis, staging, and evaluation of treatment response for lymphoma, image-based target definition and daily in-room imaging for IGRT of low contrast and diffuse-boundary lymphomas remain to be developed, especially given that lymphomas tend to be radiosensitive and do not need to be treated at high doses that could also have morbidity for adjacent tissues. Thus, this manual reflects a current status for radiotherapy of lymphomas in the modern era and is a niche book intended for a specialized audience with clinical interests in the management of lymphoma. Daniel Bourland is Associate Professor in the Department of Radiation Oncology, Wake Forest University. He teaches graduate students in the WFU Departments of Biomedical Engineering and Physics and directs a program in bioanatomic imaging and treatment. His current research interests include the uses of imaging in radiation treatment, image-based clinical trials, and small animal stereotactic radiation treatment." @default.
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• W2043160183 date "2012-01-03" @default.
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• W2043160183 title "Image-Guided Radiation Therapy in Lymphoma Management. The Increasing Role of Functional Imaging" @default.
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