FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043161960> ?p ?o ?g. }

• W2043161960 endingPage "337" @default.
• W2043161960 startingPage "327" @default.
• W2043161960 abstract "Previously, we showed that the enzymes aspartokinase (AK) and dihydrodipicolinate synthase (DDPS), which are involved in l-lysine biosynthesis in the Gram-negative obligate methylotroph Methylophilus methylotrophus AS1, were inhibited by allosteric effectors, including l-lysine. To elucidate further the regulation of l-lysine biosynthesis in M. methylotrophus, we cloned the genes encoding three other enzymes involved in this pathway, l-aspartate-β-semialdehyde dehydrogenase, dihydrodipicolinate reductase (DDPR) and diaminopimelate decarboxylase, and examined their properties. DDPR was markedly inhibited by l-lysine. Based on this and our previous results, we constructed an l-lysine-producing strain of M. methylotrophus by introducing well-characterized genes encoding desensitized forms of AK and DDPS, as well as dapB (encoding DDPR) from Escherichia coli, using a broad host range plasmid. l-Lysine production was significantly increased by employing an S-(2-aminoethyl)-l-cysteine (l-lysine analog)-resistant mutant as the host. This derivative accumulated l-lysine at a concentration of 1 g l−1 of medium using methanol as a carbon source." @default.
• W2043161960 created "2016-06-24" @default.
• W2043161960 creator A5031054926 @default.
• W2043161960 creator A5054989968 @default.
• W2043161960 creator A5058643332 @default.
• W2043161960 creator A5070419055 @default.
• W2043161960 creator A5038896718 @default.
• W2043161960 date "2006-07-01" @default.
• W2043161960 modified "2023-10-01" @default.
• W2043161960 title "l-Lysine biosynthetic pathway of Methylophilus methylotrophus and construction of an l-lysine producer" @default.
• W2043161960 cites W101455241 @default.
• W2043161960 cites W1491764194 @default.
• W2043161960 cites W1502604189 @default.
• W2043161960 cites W1505665090 @default.
• W2043161960 cites W1524417745 @default.
• W2043161960 cites W1527394822 @default.
• W2043161960 cites W1555551367 @default.
• W2043161960 cites W1559964797 @default.
• W2043161960 cites W1583063357 @default.
• W2043161960 cites W1601711255 @default.
• W2043161960 cites W1995232418 @default.
• W2043161960 cites W1997862751 @default.
• W2043161960 cites W2017021621 @default.
• W2043161960 cites W2024009600 @default.
• W2043161960 cites W2025290183 @default.
• W2043161960 cites W2036322212 @default.
• W2043161960 cites W2042305231 @default.
• W2043161960 cites W2062280300 @default.
• W2043161960 cites W2067563413 @default.
• W2043161960 cites W2083611079 @default.
• W2043161960 cites W2085569979 @default.
• W2043161960 cites W2094537314 @default.
• W2043161960 cites W2113987845 @default.
• W2043161960 cites W2132008048 @default.
• W2043161960 cites W2140214925 @default.
• W2043161960 cites W4244364268 @default.
• W2043161960 cites W4293247451 @default.
• W2043161960 doi "https://doi.org/10.1016/j.jbiotec.2005.12.026" @default.
• W2043161960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16483680" @default.
• W2043161960 hasPublicationYear "2006" @default.
• W2043161960 type Work @default.
• W2043161960 sameAs 2043161960 @default.
• W2043161960 citedByCount "31" @default.
• W2043161960 countsByYear W20431619602014 @default.
• W2043161960 countsByYear W20431619602015 @default.
• W2043161960 countsByYear W20431619602016 @default.
• W2043161960 countsByYear W20431619602017 @default.
• W2043161960 countsByYear W20431619602018 @default.
• W2043161960 countsByYear W20431619602019 @default.
• W2043161960 countsByYear W20431619602020 @default.
• W2043161960 countsByYear W20431619602022 @default.
• W2043161960 countsByYear W20431619602023 @default.
• W2043161960 crossrefType "journal-article" @default.
• W2043161960 hasAuthorship W2043161960A5031054926 @default.
• W2043161960 hasAuthorship W2043161960A5038896718 @default.
• W2043161960 hasAuthorship W2043161960A5054989968 @default.
• W2043161960 hasAuthorship W2043161960A5058643332 @default.
• W2043161960 hasAuthorship W2043161960A5070419055 @default.
• W2043161960 hasConcept C104317684 @default.
• W2043161960 hasConcept C143065580 @default.
• W2043161960 hasConcept C181199279 @default.
• W2043161960 hasConcept C185592680 @default.
• W2043161960 hasConcept C2776016237 @default.
• W2043161960 hasConcept C2776928777 @default.
• W2043161960 hasConcept C2777167505 @default.
• W2043161960 hasConcept C2779703059 @default.
• W2043161960 hasConcept C515207424 @default.
• W2043161960 hasConcept C547475151 @default.
• W2043161960 hasConcept C553450214 @default.
• W2043161960 hasConcept C55493867 @default.
• W2043161960 hasConcept C86803240 @default.
• W2043161960 hasConceptScore W2043161960C104317684 @default.
• W2043161960 hasConceptScore W2043161960C143065580 @default.
• W2043161960 hasConceptScore W2043161960C181199279 @default.
• W2043161960 hasConceptScore W2043161960C185592680 @default.
• W2043161960 hasConceptScore W2043161960C2776016237 @default.
• W2043161960 hasConceptScore W2043161960C2776928777 @default.
• W2043161960 hasConceptScore W2043161960C2777167505 @default.
• W2043161960 hasConceptScore W2043161960C2779703059 @default.
• W2043161960 hasConceptScore W2043161960C515207424 @default.
• W2043161960 hasConceptScore W2043161960C547475151 @default.
• W2043161960 hasConceptScore W2043161960C553450214 @default.
• W2043161960 hasConceptScore W2043161960C55493867 @default.
• W2043161960 hasConceptScore W2043161960C86803240 @default.
• W2043161960 hasIssue "2" @default.
• W2043161960 hasLocation W20431619601 @default.
• W2043161960 hasLocation W20431619602 @default.
• W2043161960 hasOpenAccess W2043161960 @default.
• W2043161960 hasPrimaryLocation W20431619601 @default.
• W2043161960 hasRelatedWork W1572120979 @default.
• W2043161960 hasRelatedWork W1640316177 @default.
• W2043161960 hasRelatedWork W1974395439 @default.
• W2043161960 hasRelatedWork W2019576136 @default.
• W2043161960 hasRelatedWork W2050790825 @default.
• W2043161960 hasRelatedWork W2050917233 @default.
• W2043161960 hasRelatedWork W2093818178 @default.
• W2043161960 hasRelatedWork W2418444744 @default.
• W2043161960 hasRelatedWork W2994412465 @default.

• next