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- W2043165090 abstract "the urothelial coating may be defective or even lost in IC/PBS patients, as shown recently [2], urinary compounds would infiltrate into the vesical wall and trigger inflammatory reactions and/or nerve stimulation that would ultimately account for most of the clinical manifestations of IC/PBS [1,2]. In line with its physiological role in the urothelium, GAG or physicochemically similar polymers, such as pentosanpolysulfate, have been used to repair the putatively defective coating. Often these polymers are administered singly, and they remain a mainstay in IC/PBS therapy, as well discussed by Fall, Oberpenning, and Peeker [3]. However, a GAG may also be used as an adjuvant to another polymer, such as pentosanpolysulfate, especially when the latter does not adequately improve symptoms [4]. The present review [3] is a useful critical appraisal of the many different therapies currently available for the treatment of IC/PBS, enabling the clinician to make more objective decisions. Of special interest is the inclusion of alternative treatments, a more comprehensive evaluation of surgical procedures, and the classification of the various treatments according to their level of evidence and recommendation. Although there are other recent reviews on this subject, these usually focus on pharmacologic treatments and only a few evaluate in greater detail other available therapies, notably the surgical ones [5]." @default.
- W2043165090 created "2016-06-24" @default.
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- W2043165090 date "2008-07-01" @default.
- W2043165090 modified "2023-09-25" @default.
- W2043165090 title "Editorial Comment on: Treatment of Bladder Pain Syndrome/Interstitial Cystitis 2008: Can We Make Evidence Based Decisions?" @default.
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- W2043165090 doi "https://doi.org/10.1016/j.eururo.2008.03.089" @default.
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