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• W2043187554 abstract "The liver microsomal vitamin K-dependent carboxylase catalyzes the posttranslational conversion of specific glutamate residues to gamma-carboxyglutamate residues in a limited number of proteins. A number of these proteins have been shown to contain a homologous basic amino acid-rich propeptide between the leader sequence and the amino terminus of the mature protein. Plasmids encoding protein C, a vitamin K-dependent protein, containing or lacking a propeptide region were constructed and the protein was expressed in Escherichia coli. The protein products were assayed as substrates in an in vitro vitamin K-dependent carboxylase system. Only proteins containing a propeptide region were substrates for the enzyme. These data support the hypothesis that this sequence of the primary gene product is an important recognition site for this processing enzyme." @default.
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• W2043187554 date "1987-02-01" @default.
• W2043187554 modified "2023-09-27" @default.
• W2043187554 title "Vitamin K-dependent carboxylase: possible role of the substrate propeptide as an intracellular recognition site." @default.
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• W2043187554 doi "https://doi.org/10.1073/pnas.84.3.634" @default.
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