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- W2043193405 abstract "243 Background: E1-deleted adenoviral vectors are efficient vectors for somatic gene therapy. Recently it has been shown that overexpression of Th2-cytokines may induce prolongation of allograft acceptance in different rat or mouse transplantation models. However we have observed that overexpression of the Th2-cytokine Interleukin-4 (IL-4) in rat hearts different both in MHC class I and MHC class II molecules does not induce graft acceptance despite detection of intragraft IL-4 by RT-PCR. Aim: In this study we have investigated the role of other immuneregulatory cytokines in our high responder transplantation model (DA, RT1av1→ Lewis, RT11). Methods: For this purpose adenovirus vectors encoding for viral IL-10 and rat IL-12p40 - known as endogenous inhibitor of the Th1-cytokine IL-12 - have been constructed. Following adenovirus gene transfer by injection of 5×109 plaque forming units (pfu) heterotopic heart transplantation was performed in abdominal localization. The graft survival was checked by daily palpation. Graft rejection was defined as absence of palpable heart beat. Results/Conclusions: Neither injection of AdvIL-10 nor AdIL-12p40 prolonged survival of allogeneic heart transplants (Table 1). Moreover co-application of AdvIL-10 and AdIL-12p40 or AdvIL-10 and AdrIL-4 did not lead to the prolongation of heart allograft survival. Our experimental results indicate that overexpression of Th2-cytokines or Th1-inhibitors after adenovirus-mediated gene transfer in rat allogeneic hearts is not able to prevent acute rejection of heart transplants in high responder strain combination.Table 1: Survival of rat allogeneic grafts after adenovirus-mediated gene transfer of cytokines in high responder strain combination (DA→Lewis)" @default.
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- W2043193405 date "1999-04-01" @default.
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- W2043193405 title "CYTOKINE GENE TRANSFER IN HEART ALLOGRAFTS DOES NOT INDUCE TOLERANCE IN HIGH RESPONDER STRAIN COMBINATION" @default.
- W2043193405 doi "https://doi.org/10.1097/00007890-199904150-00271" @default.
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