Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043212895> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2043212895 abstract "An active internal ribosome entry sequence (IRES) that efficiently mediates cap (m7pppGN)-independent translation in human carcinoma cells could be an effective device for gene co-transduction in cancer gene therapy. In this study using the cytomegalovirus (CMV) promoter, a remarkable internal translation activity was observed and mediated by the sequence localized to the 183-653 region of 5' NF-kappaB repressor mRNA (NFR183IRES). To test the potential of such sequence for therapeutic application, we carried out in vitro functional assays using the dicistronic constructs that internally expressed human PTEN tumor suppressor. The PTEN expression mediated by NFR183IRES was found to result in growth inhibition of carcinoma cells more effectively than the expression by NFR1IRES that contained the 1-653 region. When compared to the internal translation driven by the picornaviral IRES element of the encephalomyocarditis virus (EMCV) or the foot-and-mouth disease virus (FMDV), NFR183IRES consistently exhibited a higher activity in the human carcinoma cells, HeLa, LNCaP and MCF7. Such high-efficiency translational control element may prove useful for cancer gene therapy." @default.
- W2043212895 created "2016-06-24" @default.
- W2043212895 creator A5013843400 @default.
- W2043212895 creator A5082425428 @default.
- W2043212895 date "2002-06-01" @default.
- W2043212895 modified "2023-09-27" @default.
- W2043212895 title "A high-efficiency translational control element with potential for cancer gene therapy" @default.
- W2043212895 doi "https://doi.org/10.3892/ijo.20.6.1269" @default.
- W2043212895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12012009" @default.
- W2043212895 hasPublicationYear "2002" @default.
- W2043212895 type Work @default.
- W2043212895 sameAs 2043212895 @default.
- W2043212895 citedByCount "1" @default.
- W2043212895 crossrefType "journal-article" @default.
- W2043212895 hasAuthorship W2043212895A5013843400 @default.
- W2043212895 hasAuthorship W2043212895A5082425428 @default.
- W2043212895 hasConcept C104317684 @default.
- W2043212895 hasConcept C105580179 @default.
- W2043212895 hasConcept C111599444 @default.
- W2043212895 hasConcept C121608353 @default.
- W2043212895 hasConcept C149364088 @default.
- W2043212895 hasConcept C153911025 @default.
- W2043212895 hasConcept C159047783 @default.
- W2043212895 hasConcept C2779723316 @default.
- W2043212895 hasConcept C2781018059 @default.
- W2043212895 hasConcept C29537977 @default.
- W2043212895 hasConcept C502942594 @default.
- W2043212895 hasConcept C54355233 @default.
- W2043212895 hasConcept C77430603 @default.
- W2043212895 hasConcept C86803240 @default.
- W2043212895 hasConcept C96232424 @default.
- W2043212895 hasConceptScore W2043212895C104317684 @default.
- W2043212895 hasConceptScore W2043212895C105580179 @default.
- W2043212895 hasConceptScore W2043212895C111599444 @default.
- W2043212895 hasConceptScore W2043212895C121608353 @default.
- W2043212895 hasConceptScore W2043212895C149364088 @default.
- W2043212895 hasConceptScore W2043212895C153911025 @default.
- W2043212895 hasConceptScore W2043212895C159047783 @default.
- W2043212895 hasConceptScore W2043212895C2779723316 @default.
- W2043212895 hasConceptScore W2043212895C2781018059 @default.
- W2043212895 hasConceptScore W2043212895C29537977 @default.
- W2043212895 hasConceptScore W2043212895C502942594 @default.
- W2043212895 hasConceptScore W2043212895C54355233 @default.
- W2043212895 hasConceptScore W2043212895C77430603 @default.
- W2043212895 hasConceptScore W2043212895C86803240 @default.
- W2043212895 hasConceptScore W2043212895C96232424 @default.
- W2043212895 hasLocation W20432128951 @default.
- W2043212895 hasLocation W20432128952 @default.
- W2043212895 hasOpenAccess W2043212895 @default.
- W2043212895 hasPrimaryLocation W20432128951 @default.
- W2043212895 hasRelatedWork W1574698301 @default.
- W2043212895 hasRelatedWork W1654947539 @default.
- W2043212895 hasRelatedWork W1979596837 @default.
- W2043212895 hasRelatedWork W1980182768 @default.
- W2043212895 hasRelatedWork W1996295538 @default.
- W2043212895 hasRelatedWork W2014533868 @default.
- W2043212895 hasRelatedWork W2052805423 @default.
- W2043212895 hasRelatedWork W2057382102 @default.
- W2043212895 hasRelatedWork W2057961356 @default.
- W2043212895 hasRelatedWork W2066725395 @default.
- W2043212895 hasRelatedWork W2067024032 @default.
- W2043212895 hasRelatedWork W2073051449 @default.
- W2043212895 hasRelatedWork W2075010648 @default.
- W2043212895 hasRelatedWork W2078624419 @default.
- W2043212895 hasRelatedWork W2086340898 @default.
- W2043212895 hasRelatedWork W2121882364 @default.
- W2043212895 hasRelatedWork W2127083289 @default.
- W2043212895 hasRelatedWork W2329426079 @default.
- W2043212895 hasRelatedWork W2409067644 @default.
- W2043212895 hasRelatedWork W2465772860 @default.
- W2043212895 isParatext "false" @default.
- W2043212895 isRetracted "false" @default.
- W2043212895 magId "2043212895" @default.
- W2043212895 workType "article" @default.