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• W2043222110 endingPage "304" @default.
• W2043222110 startingPage "286" @default.
• W2043222110 abstract "Over the past few years there have been substantial advances in our knowledge of premalignant lesions of the pancreas. Given the dismal prognosis of untreated pancreatic cancer, and the small proportion of patients who are operative candidates, an understanding of these premalignant lesions is essential for the development of strategies for early diagnosis and prevention. The 2010 WHO classification has added new entities, including intraductal tubular papillary neoplasms (ITPNs), and clarified the nomenclature and grading of previously recognised precursor lesions of pancreatic adenocarcinoma, such as intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs) and pancreatic intraepithelial neoplasia (PanIN). In particular, there has been an upsurge of interest in the natural history of IPMN, driven partly by improvements in imaging modalities and the consequent apparent increase in their incidence, and partly by recognition that subtypes based on location or histological appearance define groups with significantly different behaviours. In mid 2012 revised international guidelines for the classification and management of IPMNs and MCNs were published, although in several respects these guidelines represent a consensus view rather than being evidence-based. In recent years major advances in molecular technologies, including whole-exome sequencing, have significantly enhanced our knowledge of pancreatic premalignancy and have identified potentially highly specific diagnostic biomarkers such as mutations in GNAS and RNF43 that could be used to pre-operatively assess pancreatic cysts. Over the past few years there have been substantial advances in our knowledge of premalignant lesions of the pancreas. Given the dismal prognosis of untreated pancreatic cancer, and the small proportion of patients who are operative candidates, an understanding of these premalignant lesions is essential for the development of strategies for early diagnosis and prevention. The 2010 WHO classification has added new entities, including intraductal tubular papillary neoplasms (ITPNs), and clarified the nomenclature and grading of previously recognised precursor lesions of pancreatic adenocarcinoma, such as intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs) and pancreatic intraepithelial neoplasia (PanIN). In particular, there has been an upsurge of interest in the natural history of IPMN, driven partly by improvements in imaging modalities and the consequent apparent increase in their incidence, and partly by recognition that subtypes based on location or histological appearance define groups with significantly different behaviours. In mid 2012 revised international guidelines for the classification and management of IPMNs and MCNs were published, although in several respects these guidelines represent a consensus view rather than being evidence-based. In recent years major advances in molecular technologies, including whole-exome sequencing, have significantly enhanced our knowledge of pancreatic premalignancy and have identified potentially highly specific diagnostic biomarkers such as mutations in GNAS and RNF43 that could be used to pre-operatively assess pancreatic cysts." @default.
• W2043222110 created "2016-06-24" @default.
• W2043222110 creator A5003427020 @default.
• W2043222110 creator A5049385816 @default.
• W2043222110 creator A5086908096 @default.
• W2043222110 date "2013-04-01" @default.
• W2043222110 modified "2023-10-13" @default.
• W2043222110 title "Classification, morphology and molecular pathology of premalignant lesions of the pancreas" @default.
• W2043222110 cites W1593399386 @default.
• W2043222110 cites W1787071860 @default.
• W2043222110 cites W1805092364 @default.
• W2043222110 cites W1964064067 @default.
• W2043222110 cites W1966639069 @default.
• W2043222110 cites W1966973445 @default.
• W2043222110 cites W1967197732 @default.
• W2043222110 cites W1970403897 @default.
• W2043222110 cites W1970696141 @default.
• W2043222110 cites W1970845320 @default.
• W2043222110 cites W1971218281 @default.
• W2043222110 cites W1971852262 @default.
• W2043222110 cites W1972040499 @default.
• W2043222110 cites W1972186253 @default.
• W2043222110 cites W1973453594 @default.
• W2043222110 cites W1975616447 @default.
• W2043222110 cites W1975940378 @default.
• W2043222110 cites W1977467011 @default.
• W2043222110 cites W1979006112 @default.
• W2043222110 cites W1980417198 @default.
• W2043222110 cites W1981334643 @default.
• W2043222110 cites W1982479615 @default.
• W2043222110 cites W1985838038 @default.
• W2043222110 cites W1986619901 @default.
• W2043222110 cites W1988575184 @default.
• W2043222110 cites W1989499154 @default.
• W2043222110 cites W1990815284 @default.
• W2043222110 cites W1991467715 @default.
• W2043222110 cites W1992928961 @default.
• W2043222110 cites W1993378013 @default.
• W2043222110 cites W1993421464 @default.
• W2043222110 cites W1993658673 @default.
• W2043222110 cites W1997888316 @default.
• W2043222110 cites W1998652447 @default.
• W2043222110 cites W1998658831 @default.
• W2043222110 cites W2003393109 @default.
• W2043222110 cites W2004903531 @default.
• W2043222110 cites W2005456549 @default.
• W2043222110 cites W2006818913 @default.
• W2043222110 cites W2007454937 @default.
• W2043222110 cites W2008745311 @default.
• W2043222110 cites W2010409155 @default.
• W2043222110 cites W2012055544 @default.
• W2043222110 cites W2012229838 @default.
• W2043222110 cites W2012509431 @default.
• W2043222110 cites W2013102168 @default.
• W2043222110 cites W2015116101 @default.
• W2043222110 cites W2016178651 @default.
• W2043222110 cites W2016181047 @default.
• W2043222110 cites W2018159884 @default.
• W2043222110 cites W2019917167 @default.
• W2043222110 cites W2020480128 @default.
• W2043222110 cites W2020501568 @default.
• W2043222110 cites W2022195700 @default.
• W2043222110 cites W2022459113 @default.
• W2043222110 cites W2023210471 @default.
• W2043222110 cites W2023755253 @default.
• W2043222110 cites W2033740665 @default.
• W2043222110 cites W2034117382 @default.
• W2043222110 cites W2034255342 @default.
• W2043222110 cites W2035987476 @default.
• W2043222110 cites W2037095626 @default.
• W2043222110 cites W2037881272 @default.
• W2043222110 cites W2039696693 @default.
• W2043222110 cites W2040375845 @default.
• W2043222110 cites W2040538643 @default.
• W2043222110 cites W2040610108 @default.
• W2043222110 cites W2040693082 @default.
• W2043222110 cites W2042954848 @default.
• W2043222110 cites W2043567619 @default.
• W2043222110 cites W2044023070 @default.
• W2043222110 cites W2044790491 @default.
• W2043222110 cites W2044801655 @default.
• W2043222110 cites W2045857417 @default.
• W2043222110 cites W2046429487 @default.
• W2043222110 cites W2046494853 @default.
• W2043222110 cites W2047190757 @default.
• W2043222110 cites W2047213909 @default.
• W2043222110 cites W2050079849 @default.
• W2043222110 cites W2051244930 @default.
• W2043222110 cites W2051334830 @default.
• W2043222110 cites W2052862446 @default.
• W2043222110 cites W2053275120 @default.
• W2043222110 cites W2054220377 @default.
• W2043222110 cites W2055221357 @default.
• W2043222110 cites W2056322315 @default.
• W2043222110 cites W2058668686 @default.
• W2043222110 cites W2062696188 @default.
• W2043222110 cites W2062761368 @default.
• W2043222110 cites W2063056349 @default.

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