FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043224905> ?p ?o ?g. }

• W2043224905 endingPage "206" @default.
• W2043224905 startingPage "202" @default.
• W2043224905 abstract "Very sensitive procedures were developed for the parallel determination of intestinal lactase (LPH) activity and the cognate mRNA. Between 14 and 20 weeks of gestation, lactase activity is low and varies only slightly; at 37 weeks, a relatively high level of activity is observed. The amounts of LPH mRNA correlates with the enzymatic activity ( r = 0.64). Culture of fetal jejunal explants for 5 days induces by itself a 2‐fold increase in LPH mRNA, without any significant change in lactase enzymatic activity. This increase may reflect the loss of a negative transcriptional regulation operative in vivo, and suggests all additional post‐transcriptional regulatory component. The addition of hydrocortisone (50 ng/ml) during culture induces a doubling of lactase activity without variation in LHP mRNA, indicating a post‐transcriptional modulation by hydrocortisone. The intestinal lysosomal acid β‐galactosidase activity was shown to be unaffected by hydrocortisone treatment. This observation clearly illustrates that the two intestinal β‐galactosidases are regulated differently. Our results suggests a complex developmental regulation of human intestinal lactase and that the perinatal increase in lactase activity could be modulated at a post‐transcriptional level by hydrocortisone." @default.
• W2043224905 created "2016-06-24" @default.
• W2043224905 creator A5020118294 @default.
• W2043224905 creator A5038321351 @default.
• W2043224905 creator A5076388980 @default.
• W2043224905 creator A5091724579 @default.
• W2043224905 date "1992-04-20" @default.
• W2043224905 modified "2023-09-30" @default.
• W2043224905 title "The expression of lactase enzymatic activity and mRNA in human fetal jejunum Effect of organ culture and of treatment with hydrocortisone" @default.
• W2043224905 cites W1775749144 @default.
• W2043224905 cites W1957066378 @default.
• W2043224905 cites W1989075870 @default.
• W2043224905 cites W1990205754 @default.
• W2043224905 cites W1996855258 @default.
• W2043224905 cites W200081977 @default.
• W2043224905 cites W2017410870 @default.
• W2043224905 cites W2018995260 @default.
• W2043224905 cites W2029698947 @default.
• W2043224905 cites W2068690187 @default.
• W2043224905 cites W2069026914 @default.
• W2043224905 cites W2077227518 @default.
• W2043224905 cites W2084646826 @default.
• W2043224905 cites W2092393393 @default.
• W2043224905 cites W2093296903 @default.
• W2043224905 cites W2102131116 @default.
• W2043224905 cites W2110389243 @default.
• W2043224905 cites W2134740396 @default.
• W2043224905 cites W2219619879 @default.
• W2043224905 cites W2326219279 @default.
• W2043224905 cites W2414268392 @default.
• W2043224905 cites W4293247451 @default.
• W2043224905 cites W4321429286 @default.
• W2043224905 cites W7386683 @default.
• W2043224905 doi "https://doi.org/10.1016/0014-5793(92)81248-k" @default.
• W2043224905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1568481" @default.
• W2043224905 hasPublicationYear "1992" @default.
• W2043224905 type Work @default.
• W2043224905 sameAs 2043224905 @default.
• W2043224905 citedByCount "40" @default.
• W2043224905 countsByYear W20432249052012 @default.
• W2043224905 countsByYear W20432249052013 @default.
• W2043224905 countsByYear W20432249052016 @default.
• W2043224905 countsByYear W20432249052017 @default.
• W2043224905 countsByYear W20432249052018 @default.
• W2043224905 countsByYear W20432249052021 @default.
• W2043224905 countsByYear W20432249052022 @default.
• W2043224905 crossrefType "journal-article" @default.
• W2043224905 hasAuthorship W2043224905A5020118294 @default.
• W2043224905 hasAuthorship W2043224905A5038321351 @default.
• W2043224905 hasAuthorship W2043224905A5076388980 @default.
• W2043224905 hasAuthorship W2043224905A5091724579 @default.
• W2043224905 hasConcept C104317684 @default.
• W2043224905 hasConcept C105580179 @default.
• W2043224905 hasConcept C126322002 @default.
• W2043224905 hasConcept C127561419 @default.
• W2043224905 hasConcept C134018914 @default.
• W2043224905 hasConcept C181199279 @default.
• W2043224905 hasConcept C202751555 @default.
• W2043224905 hasConcept C2778709874 @default.
• W2043224905 hasConcept C2778974006 @default.
• W2043224905 hasConcept C28212737 @default.
• W2043224905 hasConcept C28483552 @default.
• W2043224905 hasConcept C55493867 @default.
• W2043224905 hasConcept C71924100 @default.
• W2043224905 hasConcept C86803240 @default.
• W2043224905 hasConceptScore W2043224905C104317684 @default.
• W2043224905 hasConceptScore W2043224905C105580179 @default.
• W2043224905 hasConceptScore W2043224905C126322002 @default.
• W2043224905 hasConceptScore W2043224905C127561419 @default.
• W2043224905 hasConceptScore W2043224905C134018914 @default.
• W2043224905 hasConceptScore W2043224905C181199279 @default.
• W2043224905 hasConceptScore W2043224905C202751555 @default.
• W2043224905 hasConceptScore W2043224905C2778709874 @default.
• W2043224905 hasConceptScore W2043224905C2778974006 @default.
• W2043224905 hasConceptScore W2043224905C28212737 @default.
• W2043224905 hasConceptScore W2043224905C28483552 @default.
• W2043224905 hasConceptScore W2043224905C55493867 @default.
• W2043224905 hasConceptScore W2043224905C71924100 @default.
• W2043224905 hasConceptScore W2043224905C86803240 @default.
• W2043224905 hasIssue "2" @default.
• W2043224905 hasLocation W20432249051 @default.
• W2043224905 hasLocation W20432249052 @default.
• W2043224905 hasOpenAccess W2043224905 @default.
• W2043224905 hasPrimaryLocation W20432249051 @default.
• W2043224905 hasRelatedWork W1966798818 @default.
• W2043224905 hasRelatedWork W1979974556 @default.
• W2043224905 hasRelatedWork W1980194808 @default.
• W2043224905 hasRelatedWork W2000672882 @default.
• W2043224905 hasRelatedWork W2020449916 @default.
• W2043224905 hasRelatedWork W2053690201 @default.
• W2043224905 hasRelatedWork W2084912383 @default.
• W2043224905 hasRelatedWork W2098249099 @default.
• W2043224905 hasRelatedWork W2115748452 @default.
• W2043224905 hasRelatedWork W2156430177 @default.
• W2043224905 hasVolume "301" @default.
• W2043224905 isParatext "false" @default.
• W2043224905 isRetracted "false" @default.
• W2043224905 magId "2043224905" @default.

• next