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- W2043232323 endingPage "748" @default.
- W2043232323 startingPage "742" @default.
- W2043232323 abstract "Recent research has focused on proteins important for early steps in replication in eukaryotes, and particularly on Cdc6/Cdc18, the MCMs, and Cdc45. Although it is still unclear exactly what role these proteins play, it is possible that they are analogous to initiation proteins in prokaryotes. One specific model is that MCMs form a hexameric helicase at replication forks, and Cdc6/Cdc18 acts as a ‘clamp-loader’ required to lock the MCMs around DNA. The MCMs appear to be the target of Cdc7-Dbf4 kinase acting at individual replication origins. Finally, Cdc45 interacts with MCMs and may shed light on how cyclin-dependent kinases activate DNA replication." @default.
- W2043232323 created "2016-06-24" @default.
- W2043232323 creator A5044635337 @default.
- W2043232323 date "1998-12-01" @default.
- W2043232323 modified "2023-10-16" @default.
- W2043232323 title "Emerging mechanisms of eukaryotic DNA replication initiation" @default.
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- W2043232323 doi "https://doi.org/10.1016/s0955-0674(98)80117-8" @default.
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