FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043233135> ?p ?o ?g. }

• W2043233135 endingPage "151" @default.
• W2043233135 startingPage "142" @default.
• W2043233135 abstract "In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response. Oxidative stress and hyperreplication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here, we report that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage in normal human fibroblasts (NHFs) undergoing HRAS(G12V)-induced senescence. NHF-HRAS(G12V) cells underexpressed thymidylate synthase (TS) and ribonucleotide reductase (RR), two enzymes required for the entire de novo deoxyribonucleotide biosynthesis, and possessed low dNTP levels. Chromatin at the promoters of the genes encoding TS and RR was enriched with retinoblastoma tumor suppressor protein and histone H3 tri-methylated at lysine 9. Importantly, ectopic coexpression of TS and RR or addition of deoxyribonucleosides substantially suppressed DNA damage, senescence-associated phenotypes, and proliferation arrest in two types of NHF-expressing HRAS(G12V). Reciprocally, short hairpin RNA-mediated suppression of TS and RR caused DNA damage and senescence in NHFs, although less efficiently than HRAS(G12V). However, overexpression of TS and RR in quiescent NHFs did not overcome proliferation arrest, suggesting that unlike quiescence, OIS requires depletion of dNTP pools and activated DNA replication. Our data identify a previously unknown role of deoxyribonucleotides in regulation of OIS." @default.
• W2043233135 created "2016-06-24" @default.
• W2043233135 creator A5010728456 @default.
• W2043233135 creator A5017093116 @default.
• W2043233135 creator A5018684446 @default.
• W2043233135 creator A5023626926 @default.
• W2043233135 creator A5028074528 @default.
• W2043233135 creator A5028323895 @default.
• W2043233135 creator A5030208718 @default.
• W2043233135 creator A5050601416 @default.
• W2043233135 creator A5053791228 @default.
• W2043233135 creator A5061334100 @default.
• W2043233135 creator A5065737254 @default.
• W2043233135 creator A5067190256 @default.
• W2043233135 creator A5087313131 @default.
• W2043233135 date "2013-01-01" @default.
• W2043233135 modified "2023-10-16" @default.
• W2043233135 title "Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence" @default.
• W2043233135 cites W1525939557 @default.
• W2043233135 cites W1971345156 @default.
• W2043233135 cites W1977800604 @default.
• W2043233135 cites W1988876917 @default.
• W2043233135 cites W1998129814 @default.
• W2043233135 cites W2001318471 @default.
• W2043233135 cites W2002698073 @default.
• W2043233135 cites W2002869675 @default.
• W2043233135 cites W2014418062 @default.
• W2043233135 cites W2029579124 @default.
• W2043233135 cites W2033923013 @default.
• W2043233135 cites W2039341023 @default.
• W2043233135 cites W2041156660 @default.
• W2043233135 cites W2047874895 @default.
• W2043233135 cites W2059868174 @default.
• W2043233135 cites W2059971436 @default.
• W2043233135 cites W2062056341 @default.
• W2043233135 cites W2087539641 @default.
• W2043233135 cites W2089574530 @default.
• W2043233135 cites W2092167912 @default.
• W2043233135 cites W2093814864 @default.
• W2043233135 cites W2097259163 @default.
• W2043233135 cites W2102192548 @default.
• W2043233135 cites W2112196790 @default.
• W2043233135 cites W2121371748 @default.
• W2043233135 cites W2124614845 @default.
• W2043233135 cites W2149289168 @default.
• W2043233135 cites W2162561014 @default.
• W2043233135 cites W2163667875 @default.
• W2043233135 cites W2166712828 @default.
• W2043233135 cites W2320944518 @default.
• W2043233135 cites W4212962560 @default.
• W2043233135 cites W4243903519 @default.
• W2043233135 cites W94826243 @default.
• W2043233135 doi "https://doi.org/10.1016/j.ajpath.2012.09.011" @default.
• W2043233135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3532713" @default.
• W2043233135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23245831" @default.
• W2043233135 hasPublicationYear "2013" @default.
• W2043233135 type Work @default.
• W2043233135 sameAs 2043233135 @default.
• W2043233135 citedByCount "72" @default.
• W2043233135 countsByYear W20432331352012 @default.
• W2043233135 countsByYear W20432331352013 @default.
• W2043233135 countsByYear W20432331352014 @default.
• W2043233135 countsByYear W20432331352015 @default.
• W2043233135 countsByYear W20432331352016 @default.
• W2043233135 countsByYear W20432331352017 @default.
• W2043233135 countsByYear W20432331352018 @default.
• W2043233135 countsByYear W20432331352019 @default.
• W2043233135 countsByYear W20432331352020 @default.
• W2043233135 countsByYear W20432331352021 @default.
• W2043233135 countsByYear W20432331352022 @default.
• W2043233135 countsByYear W20432331352023 @default.
• W2043233135 crossrefType "journal-article" @default.
• W2043233135 hasAuthorship W2043233135A5010728456 @default.
• W2043233135 hasAuthorship W2043233135A5017093116 @default.
• W2043233135 hasAuthorship W2043233135A5018684446 @default.
• W2043233135 hasAuthorship W2043233135A5023626926 @default.
• W2043233135 hasAuthorship W2043233135A5028074528 @default.
• W2043233135 hasAuthorship W2043233135A5028323895 @default.
• W2043233135 hasAuthorship W2043233135A5030208718 @default.
• W2043233135 hasAuthorship W2043233135A5050601416 @default.
• W2043233135 hasAuthorship W2043233135A5053791228 @default.
• W2043233135 hasAuthorship W2043233135A5061334100 @default.
• W2043233135 hasAuthorship W2043233135A5065737254 @default.
• W2043233135 hasAuthorship W2043233135A5067190256 @default.
• W2043233135 hasAuthorship W2043233135A5087313131 @default.
• W2043233135 hasBestOaLocation W20432331351 @default.
• W2043233135 hasConcept C104292427 @default.
• W2043233135 hasConcept C104317684 @default.
• W2043233135 hasConcept C1167327 @default.
• W2043233135 hasConcept C134935766 @default.
• W2043233135 hasConcept C143425029 @default.
• W2043233135 hasConcept C153911025 @default.
• W2043233135 hasConcept C2781187634 @default.
• W2043233135 hasConcept C4710235 @default.
• W2043233135 hasConcept C501734568 @default.
• W2043233135 hasConcept C502942594 @default.
• W2043233135 hasConcept C522857546 @default.
• W2043233135 hasConcept C552990157 @default.

• next