Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043240939> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2043240939 endingPage "571" @default.
- W2043240939 startingPage "558" @default.
- W2043240939 abstract "In vitro studies indicate that p42/p44MAPK phosphorylate both nuclear and cytoplasmic proteins. However, the functional targets of p42/p44MAPK activation in vivo remain unclear. To address this question, we localized activated p42/p44MAPK in hippocampus and cortex and determined their signaling effects after electroconvulsive shock treatment (ECT) in rats. Phosphorylated p42/p44MAPK content increased in the cytoplasm of hippocampal neurons in response to ECT. Consistent with this cytoplasmic localization, inhibition of ECT-induced p42/p44MAPK activation by the extracellular signal-regulated kinase kinase inhibitor PD098059 blocked phosphorylation of the cytoplasmic protein microtubule-associated protein 2c (MAP2c), but failed to inhibit the induction of the nuclear protein c-Fos in response to ECT. In contrast to hippocampal neurons, cortical neurons exhibited an increase in amount of phosphorylated p42/p44MAPK in both the nucleus and cytoplasm after ECT. Accordingly, PD098059 blocked the induction of Fos-like immunoreactivity in the nuclei of cortical neurons as well as MAP2c phosphorylation in the cytoplasm. Our data indicate that both nuclear and cytoplasmic substrates can be activated by p42/p44MAPK in vivo. However, the functional targets of p42/p44MAPK signaling depend on the precise location of p42/p44MAPK within different subcellular compartments of brain regions. These results indicate unique functional pathways of p42/p44MAPK-mediated signal transduction within different brain regions in vivo." @default.
- W2043240939 created "2016-06-24" @default.
- W2043240939 creator A5010213274 @default.
- W2043240939 creator A5019910792 @default.
- W2043240939 creator A5022514799 @default.
- W2043240939 creator A5057423267 @default.
- W2043240939 creator A5066625736 @default.
- W2043240939 creator A5072020818 @default.
- W2043240939 creator A5081853343 @default.
- W2043240939 creator A5085921735 @default.
- W2043240939 date "2002-11-14" @default.
- W2043240939 modified "2023-10-15" @default.
- W2043240939 title "Region-Specific Targets of p42/p44MAPK Signaling in Rat Brain" @default.
- W2043240939 doi "https://doi.org/10.1046/j.1471-4159.1998.70020558.x" @default.
- W2043240939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9453550" @default.
- W2043240939 hasPublicationYear "2002" @default.
- W2043240939 type Work @default.
- W2043240939 sameAs 2043240939 @default.
- W2043240939 citedByCount "52" @default.
- W2043240939 countsByYear W20432409392012 @default.
- W2043240939 countsByYear W20432409392014 @default.
- W2043240939 countsByYear W20432409392015 @default.
- W2043240939 countsByYear W20432409392017 @default.
- W2043240939 countsByYear W20432409392019 @default.
- W2043240939 crossrefType "journal-article" @default.
- W2043240939 hasAuthorship W2043240939A5010213274 @default.
- W2043240939 hasAuthorship W2043240939A5019910792 @default.
- W2043240939 hasAuthorship W2043240939A5022514799 @default.
- W2043240939 hasAuthorship W2043240939A5057423267 @default.
- W2043240939 hasAuthorship W2043240939A5066625736 @default.
- W2043240939 hasAuthorship W2043240939A5072020818 @default.
- W2043240939 hasAuthorship W2043240939A5081853343 @default.
- W2043240939 hasAuthorship W2043240939A5085921735 @default.
- W2043240939 hasBestOaLocation W20432409391 @default.
- W2043240939 hasConcept C11960822 @default.
- W2043240939 hasConcept C126322002 @default.
- W2043240939 hasConcept C134018914 @default.
- W2043240939 hasConcept C148762608 @default.
- W2043240939 hasConcept C169760540 @default.
- W2043240939 hasConcept C190062978 @default.
- W2043240939 hasConcept C2781161787 @default.
- W2043240939 hasConcept C62478195 @default.
- W2043240939 hasConcept C71924100 @default.
- W2043240939 hasConcept C86803240 @default.
- W2043240939 hasConcept C95444343 @default.
- W2043240939 hasConceptScore W2043240939C11960822 @default.
- W2043240939 hasConceptScore W2043240939C126322002 @default.
- W2043240939 hasConceptScore W2043240939C134018914 @default.
- W2043240939 hasConceptScore W2043240939C148762608 @default.
- W2043240939 hasConceptScore W2043240939C169760540 @default.
- W2043240939 hasConceptScore W2043240939C190062978 @default.
- W2043240939 hasConceptScore W2043240939C2781161787 @default.
- W2043240939 hasConceptScore W2043240939C62478195 @default.
- W2043240939 hasConceptScore W2043240939C71924100 @default.
- W2043240939 hasConceptScore W2043240939C86803240 @default.
- W2043240939 hasConceptScore W2043240939C95444343 @default.
- W2043240939 hasIssue "2" @default.
- W2043240939 hasLocation W20432409391 @default.
- W2043240939 hasLocation W20432409392 @default.
- W2043240939 hasOpenAccess W2043240939 @default.
- W2043240939 hasPrimaryLocation W20432409391 @default.
- W2043240939 hasRelatedWork W1501306774 @default.
- W2043240939 hasRelatedWork W1985901002 @default.
- W2043240939 hasRelatedWork W2010108080 @default.
- W2043240939 hasRelatedWork W2023696391 @default.
- W2043240939 hasRelatedWork W2051942816 @default.
- W2043240939 hasRelatedWork W2138730144 @default.
- W2043240939 hasRelatedWork W2375813713 @default.
- W2043240939 hasRelatedWork W2471720107 @default.
- W2043240939 hasRelatedWork W3033872672 @default.
- W2043240939 hasRelatedWork W4312012087 @default.
- W2043240939 hasVolume "70" @default.
- W2043240939 isParatext "false" @default.
- W2043240939 isRetracted "false" @default.
- W2043240939 magId "2043240939" @default.
- W2043240939 workType "article" @default.