Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043247918> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2043247918 endingPage "728" @default.
- W2043247918 startingPage "722" @default.
- W2043247918 abstract "Fesoterodine is a pro-drug of the active metabolite 5-hydroxymethyl tolterodine (5-HMT), a muscarinic receptor antagonist. This study aimed to evaluate the safety profile and pharmacokinetic characteristics of multiple oral doses of sustained-release fesoterodine (fesoterodine SR) in healthy Korean males.A randomized, double-blind, placebo-controlled, multiple-dose study with two oral doses (4 mg and 8 mg) was conducted in healthy Korean male participants. The study drug was administered once daily for 5 days. The plasma concentration of 5-HMT was measured up to 72 hours after the last drug administration. The CYP2D6 genotype was analyzed using polymerase chain reaction (PCR) methods to assess the effect of genetic polymorphisms on the pharmacokinetic parameters.20 participants completed the study. The mean (SD) areas under the plasma concentration-time curves during the dosing interval (AUCτ) of the 4 mg and 8 mg dose groups were 26.1 (8.0) and 64.2 (30.5) μg·h/ml and the mean peak concentrations (Cmax) were 2.6 (0.7) and 6.0 (2.0) μg/ml, respectively, at steady-state. The mean AUCτ and Cmax of 5-HMT increased in approximately the same proportion as the dose increased. Fesoterodine SR was well tolerated without any serious adverse events or abnormal clinical laboratory findings.Systemic 5-HMT exposure showed dose-proportional characteristics in the 4 mg to 8 mg dose range in healthy Korean males. Thus, 4 mg or 8 mg doses of fesoterodine SR taken once-daily were tolerable in healthy Korean males." @default.
- W2043247918 created "2016-06-24" @default.
- W2043247918 creator A5010511274 @default.
- W2043247918 creator A5022675590 @default.
- W2043247918 creator A5040744205 @default.
- W2043247918 creator A5050885102 @default.
- W2043247918 creator A5058122688 @default.
- W2043247918 creator A5067914247 @default.
- W2043247918 creator A5072556204 @default.
- W2043247918 creator A5076937960 @default.
- W2043247918 date "2012-10-01" @default.
- W2043247918 modified "2023-09-27" @default.
- W2043247918 title "Multiple-dose pharmacokinetics of fesoterodine sustained-release in healthy Korean volunteers" @default.
- W2043247918 doi "https://doi.org/10.5414/cp201708" @default.
- W2043247918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22853865" @default.
- W2043247918 hasPublicationYear "2012" @default.
- W2043247918 type Work @default.
- W2043247918 sameAs 2043247918 @default.
- W2043247918 citedByCount "1" @default.
- W2043247918 countsByYear W20432479182015 @default.
- W2043247918 crossrefType "journal-article" @default.
- W2043247918 hasAuthorship W2043247918A5010511274 @default.
- W2043247918 hasAuthorship W2043247918A5022675590 @default.
- W2043247918 hasAuthorship W2043247918A5040744205 @default.
- W2043247918 hasAuthorship W2043247918A5050885102 @default.
- W2043247918 hasAuthorship W2043247918A5058122688 @default.
- W2043247918 hasAuthorship W2043247918A5067914247 @default.
- W2043247918 hasAuthorship W2043247918A5072556204 @default.
- W2043247918 hasAuthorship W2043247918A5076937960 @default.
- W2043247918 hasConcept C112705442 @default.
- W2043247918 hasConcept C126322002 @default.
- W2043247918 hasConcept C142724271 @default.
- W2043247918 hasConcept C149151106 @default.
- W2043247918 hasConcept C197934379 @default.
- W2043247918 hasConcept C204787440 @default.
- W2043247918 hasConcept C22979827 @default.
- W2043247918 hasConcept C27081682 @default.
- W2043247918 hasConcept C2777056448 @default.
- W2043247918 hasConcept C2777288759 @default.
- W2043247918 hasConcept C2777477808 @default.
- W2043247918 hasConcept C33664856 @default.
- W2043247918 hasConcept C526171541 @default.
- W2043247918 hasConcept C62231903 @default.
- W2043247918 hasConcept C71924100 @default.
- W2043247918 hasConcept C76318530 @default.
- W2043247918 hasConcept C98274493 @default.
- W2043247918 hasConceptScore W2043247918C112705442 @default.
- W2043247918 hasConceptScore W2043247918C126322002 @default.
- W2043247918 hasConceptScore W2043247918C142724271 @default.
- W2043247918 hasConceptScore W2043247918C149151106 @default.
- W2043247918 hasConceptScore W2043247918C197934379 @default.
- W2043247918 hasConceptScore W2043247918C204787440 @default.
- W2043247918 hasConceptScore W2043247918C22979827 @default.
- W2043247918 hasConceptScore W2043247918C27081682 @default.
- W2043247918 hasConceptScore W2043247918C2777056448 @default.
- W2043247918 hasConceptScore W2043247918C2777288759 @default.
- W2043247918 hasConceptScore W2043247918C2777477808 @default.
- W2043247918 hasConceptScore W2043247918C33664856 @default.
- W2043247918 hasConceptScore W2043247918C526171541 @default.
- W2043247918 hasConceptScore W2043247918C62231903 @default.
- W2043247918 hasConceptScore W2043247918C71924100 @default.
- W2043247918 hasConceptScore W2043247918C76318530 @default.
- W2043247918 hasConceptScore W2043247918C98274493 @default.
- W2043247918 hasIssue "10" @default.
- W2043247918 hasLocation W20432479181 @default.
- W2043247918 hasLocation W20432479182 @default.
- W2043247918 hasOpenAccess W2043247918 @default.
- W2043247918 hasPrimaryLocation W20432479181 @default.
- W2043247918 hasRelatedWork W105896576 @default.
- W2043247918 hasRelatedWork W1998356222 @default.
- W2043247918 hasRelatedWork W2007079254 @default.
- W2043247918 hasRelatedWork W2020497888 @default.
- W2043247918 hasRelatedWork W2028112905 @default.
- W2043247918 hasRelatedWork W2056938528 @default.
- W2043247918 hasRelatedWork W2081460129 @default.
- W2043247918 hasRelatedWork W2129599217 @default.
- W2043247918 hasRelatedWork W2151580563 @default.
- W2043247918 hasRelatedWork W3120625362 @default.
- W2043247918 hasVolume "50" @default.
- W2043247918 isParatext "false" @default.
- W2043247918 isRetracted "false" @default.
- W2043247918 magId "2043247918" @default.
- W2043247918 workType "article" @default.