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- W2043256276 abstract "Ligand binding at many physiologically relevant receptors is regulated by divalent cations. To determine whether [ 3 H]-spiroperidol binding sites in prefrontal cortex might be physiologically relevant receptors, we examined the effect of ions on the binding of this ligand in postmortem human prefrontal cortex. Our results indicate that several cations decreased [ 3 H]-spiroperidol binding in a dose-dependent fashion. Of these, Cd ++ and Zn ++ were the most able to decrease [ 3 H]-spiroperidol binding with IC 50 of 5.5.5 +/− 2.4 × 10 −6 M and 5.6 +/− 1.1 × 10 −5 M respectively. These findings indicate that [ 3 H]-spiroperidol may bind at physiologically relevant receptors in human prefrontal cortex." @default.
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- W2043256276 date "1986-04-01" @default.
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- W2043256276 title "Cations decrease specific [3H]-spiroperidol binding in human prefrontal cortex" @default.
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- W2043256276 doi "https://doi.org/10.1016/0024-3205(86)90469-8" @default.
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