FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043267002> ?p ?o ?g. }

• W2043267002 endingPage "198" @default.
• W2043267002 startingPage "187" @default.
• W2043267002 abstract "α1-Adrenoceptor agonists ((−)-adrenaline = (−)-noradrenaline å l-phenylephrine > methoxamine > (−)-(4aR,10aR)-3,4,4a,5,10,10a-hexahydro-6-methoxy-4-methyl-9-methylthio-2H-naphth[2,3-b]-1,4-oxazine (SDZ NVI 085) > cirazoline) evoked contraction of isolated mouse spleen strips, whereas oxymetazoline and indanidine were nearly inactive. Splenic contractions elicited by (−)-noradrenaline were inhibited by chloroethylclonidine (3 × 10−6–6 × 10−5 M) and partially attenuated by SZL-49 (10−7–10−6 M), but remained resistant to (±)-isradipine (10−9–10−7 M). The contractions were competitively antagonized by low concentrations of the α1B-adrenoceptor-selective antagonist, spiperone (pA2 = 8.29), but by relatively high concentrations of the α1A-adrenoceptor-selective receptor antagonists, tamsulosin (pA2 = 8.62), 5-methyl-urapidil (pA2 = 7.03), (+)-niguldipine (pA2 = 6.26) and the α1D-adrenoceptor-selective antagonist, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro-[4.5]decane-7,9-dione (BMY 7378) (pA2 = 6.76). Functional antagonist affinities at mouse spleen α1-adrenoceptors were consistent with those at guinea-pig splenic α1B-adrenoceptors, but not with those of either rat vas deferens α1A- or rat aortic α1D-adrenoceptors. Antagonist affinities at mouse spleen α1-adrenoceptors correlated also best with published antagonist data on cloned and expressed α1b-adrenoceptors but less well with those for either α1a- or α1d-adrenoceptors. The results provide pharmacological evidence that the α1-adrenoceptor mediating smooth muscle contraction of mouse spleen is the B subtype." @default.
• W2043267002 created "2016-06-24" @default.
• W2043267002 creator A5039802032 @default.
• W2043267002 date "1996-09-01" @default.
• W2043267002 modified "2023-10-03" @default.
• W2043267002 title "Functional evidence for an α1B-adrenoceptor mediating contraction of the mouse spleen" @default.
• W2043267002 cites W1586068082 @default.
• W2043267002 cites W1965679683 @default.
• W2043267002 cites W1976632125 @default.
• W2043267002 cites W1985993212 @default.
• W2043267002 cites W1996116179 @default.
• W2043267002 cites W1999624323 @default.
• W2043267002 cites W1999885957 @default.
• W2043267002 cites W2005053758 @default.
• W2043267002 cites W2005367229 @default.
• W2043267002 cites W2005880511 @default.
• W2043267002 cites W2007003323 @default.
• W2043267002 cites W2010346714 @default.
• W2043267002 cites W2011880754 @default.
• W2043267002 cites W2020404323 @default.
• W2043267002 cites W2022743180 @default.
• W2043267002 cites W2026353266 @default.
• W2043267002 cites W2029037328 @default.
• W2043267002 cites W2033179874 @default.
• W2043267002 cites W2058437932 @default.
• W2043267002 cites W2073908817 @default.
• W2043267002 cites W2075667355 @default.
• W2043267002 cites W2092532253 @default.
• W2043267002 cites W2094252861 @default.
• W2043267002 cites W2094806500 @default.
• W2043267002 cites W2172313765 @default.
• W2043267002 cites W2949328385 @default.
• W2043267002 doi "https://doi.org/10.1016/0014-2999(96)00430-x" @default.
• W2043267002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8891599" @default.
• W2043267002 hasPublicationYear "1996" @default.
• W2043267002 type Work @default.
• W2043267002 sameAs 2043267002 @default.
• W2043267002 citedByCount "35" @default.
• W2043267002 countsByYear W20432670022012 @default.
• W2043267002 countsByYear W20432670022015 @default.
• W2043267002 countsByYear W20432670022016 @default.
• W2043267002 countsByYear W20432670022020 @default.
• W2043267002 countsByYear W20432670022021 @default.
• W2043267002 countsByYear W20432670022023 @default.
• W2043267002 crossrefType "journal-article" @default.
• W2043267002 hasAuthorship W2043267002A5039802032 @default.
• W2043267002 hasConcept C126322002 @default.
• W2043267002 hasConcept C134018914 @default.
• W2043267002 hasConcept C163415756 @default.
• W2043267002 hasConcept C170493617 @default.
• W2043267002 hasConcept C185592680 @default.
• W2043267002 hasConcept C2776885963 @default.
• W2043267002 hasConcept C2777952589 @default.
• W2043267002 hasConcept C2778210472 @default.
• W2043267002 hasConcept C2778938600 @default.
• W2043267002 hasConcept C2780042274 @default.
• W2043267002 hasConcept C2780745239 @default.
• W2043267002 hasConcept C2781073084 @default.
• W2043267002 hasConcept C40465926 @default.
• W2043267002 hasConcept C71924100 @default.
• W2043267002 hasConcept C84393581 @default.
• W2043267002 hasConcept C86803240 @default.
• W2043267002 hasConcept C98274493 @default.
• W2043267002 hasConceptScore W2043267002C126322002 @default.
• W2043267002 hasConceptScore W2043267002C134018914 @default.
• W2043267002 hasConceptScore W2043267002C163415756 @default.
• W2043267002 hasConceptScore W2043267002C170493617 @default.
• W2043267002 hasConceptScore W2043267002C185592680 @default.
• W2043267002 hasConceptScore W2043267002C2776885963 @default.
• W2043267002 hasConceptScore W2043267002C2777952589 @default.
• W2043267002 hasConceptScore W2043267002C2778210472 @default.
• W2043267002 hasConceptScore W2043267002C2778938600 @default.
• W2043267002 hasConceptScore W2043267002C2780042274 @default.
• W2043267002 hasConceptScore W2043267002C2780745239 @default.
• W2043267002 hasConceptScore W2043267002C2781073084 @default.
• W2043267002 hasConceptScore W2043267002C40465926 @default.
• W2043267002 hasConceptScore W2043267002C71924100 @default.
• W2043267002 hasConceptScore W2043267002C84393581 @default.
• W2043267002 hasConceptScore W2043267002C86803240 @default.
• W2043267002 hasConceptScore W2043267002C98274493 @default.
• W2043267002 hasIssue "2-3" @default.
• W2043267002 hasLocation W20432670021 @default.
• W2043267002 hasLocation W20432670022 @default.
• W2043267002 hasOpenAccess W2043267002 @default.
• W2043267002 hasPrimaryLocation W20432670021 @default.
• W2043267002 hasRelatedWork W1965781866 @default.
• W2043267002 hasRelatedWork W1992842231 @default.
• W2043267002 hasRelatedWork W2033057476 @default.
• W2043267002 hasRelatedWork W2043267002 @default.
• W2043267002 hasRelatedWork W2070138126 @default.
• W2043267002 hasRelatedWork W2091096287 @default.
• W2043267002 hasRelatedWork W2136506758 @default.
• W2043267002 hasRelatedWork W2163966674 @default.
• W2043267002 hasRelatedWork W2298630267 @default.
• W2043267002 hasRelatedWork W4251709836 @default.
• W2043267002 hasVolume "311" @default.
• W2043267002 isParatext "false" @default.
• W2043267002 isRetracted "false" @default.

• next