FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043268354> ?p ?o ?g. }

• W2043268354 endingPage "317" @default.
• W2043268354 startingPage "312" @default.
• W2043268354 abstract "Abstract: Activated neutrophils are assumed to be one plausible cause of tissue injury in the ischaemic and reperfused myocardium. We studied the inhibitory effects of the calcium antagonists felodipine, nimodipine and verapamil on human neutrophil activation in order to elucidate the mechanisms underlying their myocardioprotective effects and to determine whether calcium antagonists with different chemical structures vary in their effect on neutrophil activation. Neutrophils were stimulated with formyl-Met-Leu-Phe (0.1 μM) or by phorbol myristate acetate (0.16 μM), and the rise in cytosolic calcium and the H2O2 production were determined. For felodipine, the inhibitory effect on granulocyte elastase release was also studied. The calcium antagonists reduced formyl-Met-Leu-Phe and phorbol myristate acetate-induced neutrophil activation in a concentration-dependent manner, the order of potency being: felodipine >nimodipine >verapamil. For felodipine, the IC50 (concentration causing 50% reduction) values were 3×10−6 and 2×10−6 M for the formyl-Met-Leu-Phe-induced cytosolic calcium increase and H2O2 production, respectively. The IC50 -value for the phorbol myristate acetate-induced cytosolic calcium increase was 6×10−6 and for H2O2 production 4×10−6 M. For formyl-Met-Leu-Phe-induced granulocyte elastase release, the IC50-value was 5×10−6 M. The inhibitory effect of felodipine on the phorbol myristate acetate-induced granulocyte elastase release did not exceed 50%. Nimodipine was a less potent inhibitor than felodipine for both formyl-Met-Leu-Phe- and phorbol myristate acetate-induced cell activities. Verapamil was even less potent than the other two agents. The present study demonstrates that felodipine potentially suppresses neutrophil activation at micromolar concentrations. However, this observation should not be directly extrapolated to explain the tissue protection by the compounds without evidence of profound local accumulation." @default.
• W2043268354 created "2016-06-24" @default.
• W2043268354 creator A5003610520 @default.
• W2043268354 creator A5028592265 @default.
• W2043268354 creator A5049685050 @default.
• W2043268354 creator A5056330865 @default.
• W2043268354 creator A5071773009 @default.
• W2043268354 date "1996-12-01" @default.
• W2043268354 modified "2023-10-16" @default.
• W2043268354 title "Effects of Calcium Blockers on the Cytosolic Calcium, H₂O₂Production and Elastase Release in Human Neutrophils" @default.
• W2043268354 cites W1555388714 @default.
• W2043268354 cites W1556528051 @default.
• W2043268354 cites W1594758412 @default.
• W2043268354 cites W1606716377 @default.
• W2043268354 cites W1969539602 @default.
• W2043268354 cites W1974316692 @default.
• W2043268354 cites W1992575393 @default.
• W2043268354 cites W1998271889 @default.
• W2043268354 cites W2005986713 @default.
• W2043268354 cites W2011181270 @default.
• W2043268354 cites W2011513090 @default.
• W2043268354 cites W2013247387 @default.
• W2043268354 cites W2017027147 @default.
• W2043268354 cites W2022330306 @default.
• W2043268354 cites W2031878584 @default.
• W2043268354 cites W2044538987 @default.
• W2043268354 cites W2048268033 @default.
• W2043268354 cites W2050572185 @default.
• W2043268354 cites W2062350358 @default.
• W2043268354 cites W2151067784 @default.
• W2043268354 cites W2155635502 @default.
• W2043268354 cites W2233102600 @default.
• W2043268354 cites W2464667588 @default.
• W2043268354 cites W2482678799 @default.
• W2043268354 cites W4229502551 @default.
• W2043268354 cites W953271884 @default.
• W2043268354 doi "https://doi.org/10.1111/j.1600-0773.1996.tb00015.x" @default.
• W2043268354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9000258" @default.
• W2043268354 hasPublicationYear "1996" @default.
• W2043268354 type Work @default.
• W2043268354 sameAs 2043268354 @default.
• W2043268354 citedByCount "13" @default.
• W2043268354 countsByYear W20432683542017 @default.
• W2043268354 countsByYear W20432683542023 @default.
• W2043268354 crossrefType "journal-article" @default.
• W2043268354 hasAuthorship W2043268354A5003610520 @default.
• W2043268354 hasAuthorship W2043268354A5028592265 @default.
• W2043268354 hasAuthorship W2043268354A5049685050 @default.
• W2043268354 hasAuthorship W2043268354A5056330865 @default.
• W2043268354 hasAuthorship W2043268354A5071773009 @default.
• W2043268354 hasConcept C126322002 @default.
• W2043268354 hasConcept C134018914 @default.
• W2043268354 hasConcept C178790620 @default.
• W2043268354 hasConcept C181199279 @default.
• W2043268354 hasConcept C185592680 @default.
• W2043268354 hasConcept C195794163 @default.
• W2043268354 hasConcept C202751555 @default.
• W2043268354 hasConcept C2776326425 @default.
• W2043268354 hasConcept C2777022698 @default.
• W2043268354 hasConcept C2777294900 @default.
• W2043268354 hasConcept C2777752497 @default.
• W2043268354 hasConcept C2777983669 @default.
• W2043268354 hasConcept C2780043322 @default.
• W2043268354 hasConcept C2780648877 @default.
• W2043268354 hasConcept C2781044401 @default.
• W2043268354 hasConcept C519063684 @default.
• W2043268354 hasConcept C55493867 @default.
• W2043268354 hasConcept C71924100 @default.
• W2043268354 hasConcept C84393581 @default.
• W2043268354 hasConcept C98274493 @default.
• W2043268354 hasConceptScore W2043268354C126322002 @default.
• W2043268354 hasConceptScore W2043268354C134018914 @default.
• W2043268354 hasConceptScore W2043268354C178790620 @default.
• W2043268354 hasConceptScore W2043268354C181199279 @default.
• W2043268354 hasConceptScore W2043268354C185592680 @default.
• W2043268354 hasConceptScore W2043268354C195794163 @default.
• W2043268354 hasConceptScore W2043268354C202751555 @default.
• W2043268354 hasConceptScore W2043268354C2776326425 @default.
• W2043268354 hasConceptScore W2043268354C2777022698 @default.
• W2043268354 hasConceptScore W2043268354C2777294900 @default.
• W2043268354 hasConceptScore W2043268354C2777752497 @default.
• W2043268354 hasConceptScore W2043268354C2777983669 @default.
• W2043268354 hasConceptScore W2043268354C2780043322 @default.
• W2043268354 hasConceptScore W2043268354C2780648877 @default.
• W2043268354 hasConceptScore W2043268354C2781044401 @default.
• W2043268354 hasConceptScore W2043268354C519063684 @default.
• W2043268354 hasConceptScore W2043268354C55493867 @default.
• W2043268354 hasConceptScore W2043268354C71924100 @default.
• W2043268354 hasConceptScore W2043268354C84393581 @default.
• W2043268354 hasConceptScore W2043268354C98274493 @default.
• W2043268354 hasIssue "6" @default.
• W2043268354 hasLocation W20432683541 @default.
• W2043268354 hasLocation W20432683542 @default.
• W2043268354 hasOpenAccess W2043268354 @default.
• W2043268354 hasPrimaryLocation W20432683541 @default.
• W2043268354 hasRelatedWork W1978618357 @default.
• W2043268354 hasRelatedWork W2003842308 @default.
• W2043268354 hasRelatedWork W2037982983 @default.

• next