FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043274623> ?p ?o ?g. }

• W2043274623 endingPage "806" @default.
• W2043274623 startingPage "801" @default.
• W2043274623 abstract "Calcium channel blockers (CCBs) are among the most widely used drugs in cardiovascular medicine. In this study, nine CCBs (amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem) were investigated to assess the relationship between their molecular properties and elimination data obtained from literature. The descriptors of the molecular properties of CCBs were calculated using three software packages. The relationship between computed molecular properties and elimination data collected from relevant literature, initially investigated with simple linear regression analysis, showed poor correlation (R2 <0.25). Application of molecular weight or volume data as additional independent variable, multiple linear regression (MLR) revealed better correlations (R2 ~ 0.38) between CCB renal and fecal elimination data and their lipophilicity. Excluding nimodipine from the calculations resulted in more acceptable correlations. The best correlations were established after computed lipophilicity descriptor and molecular weight were applied (R2 = 0.66 with acceptable probability value)." @default.
• W2043274623 created "2016-06-24" @default.
• W2043274623 creator A5035171755 @default.
• W2043274623 creator A5041003267 @default.
• W2043274623 creator A5060287509 @default.
• W2043274623 creator A5065995737 @default.
• W2043274623 creator A5085560228 @default.
• W2043274623 date "2015-01-01" @default.
• W2043274623 modified "2023-10-16" @default.
• W2043274623 title "The effect of the molecular properties of calcium channel blockers on their elimination route" @default.
• W2043274623 cites W1497786412 @default.
• W2043274623 cites W1970857596 @default.
• W2043274623 cites W1973953734 @default.
• W2043274623 cites W1973954401 @default.
• W2043274623 cites W1989302050 @default.
• W2043274623 cites W2022507089 @default.
• W2043274623 cites W2027666102 @default.
• W2043274623 cites W2052907531 @default.
• W2043274623 cites W2062072559 @default.
• W2043274623 cites W2069506489 @default.
• W2043274623 cites W2084020918 @default.
• W2043274623 cites W2096956997 @default.
• W2043274623 cites W2098943395 @default.
• W2043274623 cites W2113656727 @default.
• W2043274623 cites W2139329419 @default.
• W2043274623 cites W2143420287 @default.
• W2043274623 cites W2151694328 @default.
• W2043274623 cites W2157970175 @default.
• W2043274623 cites W2413850517 @default.
• W2043274623 doi "https://doi.org/10.2298/abs150127039t" @default.
• W2043274623 hasPublicationYear "2015" @default.
• W2043274623 type Work @default.
• W2043274623 sameAs 2043274623 @default.
• W2043274623 citedByCount "4" @default.
• W2043274623 countsByYear W20432746232017 @default.
• W2043274623 countsByYear W20432746232021 @default.
• W2043274623 countsByYear W20432746232022 @default.
• W2043274623 crossrefType "journal-article" @default.
• W2043274623 hasAuthorship W2043274623A5035171755 @default.
• W2043274623 hasAuthorship W2043274623A5041003267 @default.
• W2043274623 hasAuthorship W2043274623A5060287509 @default.
• W2043274623 hasAuthorship W2043274623A5065995737 @default.
• W2043274623 hasAuthorship W2043274623A5085560228 @default.
• W2043274623 hasBestOaLocation W20432746231 @default.
• W2043274623 hasConcept C105795698 @default.
• W2043274623 hasConcept C126322002 @default.
• W2043274623 hasConcept C185592680 @default.
• W2043274623 hasConcept C201399114 @default.
• W2043274623 hasConcept C2776066529 @default.
• W2043274623 hasConcept C2776271655 @default.
• W2043274623 hasConcept C2776741139 @default.
• W2043274623 hasConcept C2777022698 @default.
• W2043274623 hasConcept C2777294900 @default.
• W2043274623 hasConcept C2778043224 @default.
• W2043274623 hasConcept C2779066535 @default.
• W2043274623 hasConcept C2779646130 @default.
• W2043274623 hasConcept C2780648877 @default.
• W2043274623 hasConcept C2781212610 @default.
• W2043274623 hasConcept C33923547 @default.
• W2043274623 hasConcept C48921125 @default.
• W2043274623 hasConcept C519063684 @default.
• W2043274623 hasConcept C71240020 @default.
• W2043274623 hasConcept C71924100 @default.
• W2043274623 hasConcept C84393581 @default.
• W2043274623 hasConcept C85520022 @default.
• W2043274623 hasConcept C98274493 @default.
• W2043274623 hasConceptScore W2043274623C105795698 @default.
• W2043274623 hasConceptScore W2043274623C126322002 @default.
• W2043274623 hasConceptScore W2043274623C185592680 @default.
• W2043274623 hasConceptScore W2043274623C201399114 @default.
• W2043274623 hasConceptScore W2043274623C2776066529 @default.
• W2043274623 hasConceptScore W2043274623C2776271655 @default.
• W2043274623 hasConceptScore W2043274623C2776741139 @default.
• W2043274623 hasConceptScore W2043274623C2777022698 @default.
• W2043274623 hasConceptScore W2043274623C2777294900 @default.
• W2043274623 hasConceptScore W2043274623C2778043224 @default.
• W2043274623 hasConceptScore W2043274623C2779066535 @default.
• W2043274623 hasConceptScore W2043274623C2779646130 @default.
• W2043274623 hasConceptScore W2043274623C2780648877 @default.
• W2043274623 hasConceptScore W2043274623C2781212610 @default.
• W2043274623 hasConceptScore W2043274623C33923547 @default.
• W2043274623 hasConceptScore W2043274623C48921125 @default.
• W2043274623 hasConceptScore W2043274623C519063684 @default.
• W2043274623 hasConceptScore W2043274623C71240020 @default.
• W2043274623 hasConceptScore W2043274623C71924100 @default.
• W2043274623 hasConceptScore W2043274623C84393581 @default.
• W2043274623 hasConceptScore W2043274623C85520022 @default.
• W2043274623 hasConceptScore W2043274623C98274493 @default.
• W2043274623 hasFunder F4320322729 @default.
• W2043274623 hasIssue "3" @default.
• W2043274623 hasLocation W20432746231 @default.
• W2043274623 hasLocation W20432746232 @default.
• W2043274623 hasOpenAccess W2043274623 @default.
• W2043274623 hasPrimaryLocation W20432746231 @default.
• W2043274623 hasRelatedWork W18325119 @default.
• W2043274623 hasRelatedWork W2033902643 @default.
• W2043274623 hasRelatedWork W2043274623 @default.
• W2043274623 hasRelatedWork W2413265658 @default.

• next