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• W2043280049 startingPage "1695" @default.
• W2043280049 abstract "Oxidative stress increases during unloading in muscle from young adult rats. The present study examined the markers of oxidative stress and antioxidant enzyme gene and protein expressions in medial gastrocnemius muscles of aged and young adult (30 and 6 mo of age) Fischer 344 × Brown Norway rats after 14 days of hindlimb suspension. Medial gastrocnemius muscle weight was decreased by ∼30% in young adult and aged rats following suspension. When muscle weight was normalized to animal body weight, it was reduced by 12% and 22% in young adult and aged rats, respectively, after suspension. Comparisons between young adult and aged control animals demonstrated a 25% and 51% decline in muscle mass when expressed as absolute muscle weight and muscle weight normalized to the animal body weight, respectively. H 2 O 2 content was elevated by 43% while Mn superoxide dismutase (MnSOD) protein content was reduced by 28% in suspended muscles compared with control muscles exclusively in the aged animals. Suspended muscles had greater content of malondialdehyde (MDA)/4-hydroxyalkenals (4-HAE) (29% and 58% increase in young adult and aged rats, respectively), nitrotyrosine (76% and 65% increase in young adult and aged rats, respectively), and catalase activity (69% and 43% increase in young adult and aged rats, respectively) relative to control muscles. Changes in oxidative stress markers MDA/4-HAE, H 2 O 2 , and MnSOD protein contents in response to hindlimb unloading occurred in an age-dependent manner. These findings are consistent with the hypotheses that oxidative stress has a role in mediating disuse-induced and sarcopenia-associated muscle losses. Our data suggest that aging may predispose skeletal muscle to increased levels of oxidative stress both at rest and during unloading." @default.
• W2043280049 created "2016-06-24" @default.
• W2043280049 creator A5046377450 @default.
• W2043280049 creator A5055327049 @default.
• W2043280049 creator A5089902930 @default.
• W2043280049 date "2008-12-01" @default.
• W2043280049 modified "2023-10-17" @default.
• W2043280049 title "Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading" @default.
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• W2043280049 doi "https://doi.org/10.1152/japplphysiol.90800.2008" @default.
• W2043280049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2612472" @default.
• W2043280049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18801960" @default.
• W2043280049 hasPublicationYear "2008" @default.
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