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• W2043281349 endingPage "713" @default.
• W2043281349 startingPage "701" @default.
• W2043281349 abstract "HIV-1 transgenic (Tg) rats, a model for human HIV-1 associated neurocognitive disorder (HAND), show upregulated markers of brain arachidonic acid (AA) metabolism with neuroinflammation after 7 months of age. Since lithium decreases AA metabolism in a rat lipopolysaccharide model of neuroinflammation, and may be useful in HAND, we hypothesized that lithium would dampen upregulated brain AA metabolism in HIV-1 Tg rats. Regional brain AA incorporation coefficients k* and rates J in , markers of AA signaling and metabolism, were measured in 81 brain regions using quantitative autoradiography, after intravenous [1-14 C]AA infusion in unanesthetized 10-month-old HIV-1 Tg and age-matched wildtype rats that had been fed a control or LiCl diet for 6 weeks. k* and J in for AA were significantly higher in HIV-1 Tg than wildtype rats fed the control diet. Lithium feeding reduced plasma unesterified AA concentration in both groups and J in in wildtype rats, and blocked increments in k* (19 of 54 regions) and J in (77 of 81 regions) in HIV-1 Tg rats. These in vivo neuroimaging data indicate that lithium treatment dampened upregulated brain AA metabolism in HIV-1 Tg rats. Lithium may improve cognitive dysfunction and be neuroprotective in HIV-1 patients with HAND through a comparable effect." @default.
• W2043281349 created "2016-06-24" @default.
• W2043281349 creator A5011234589 @default.
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• W2043281349 creator A5059116543 @default.
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• W2043281349 date "2012-07-04" @default.
• W2043281349 modified "2023-09-26" @default.
• W2043281349 title "Chronic Lithium Feeding Reduces Upregulated Brain Arachidonic Acid Metabolism in HIV-1 Transgenic Rat" @default.
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• W2043281349 doi "https://doi.org/10.1007/s11481-012-9381-0" @default.
• W2043281349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3478068" @default.
• W2043281349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22760927" @default.

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