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- W2043282209 abstract "The metabolism of cytoplasmic, nucleolar and chromosomal RNA was studied at various time intervals ranging from 6 to 120 minutes in the liver of the 21-day-old progeny of well-fed and dietary restricted rats. The dietary-restricted group's progeny demonstrated significant increases in the kinetics of labelling of cytoplasmic RNA (p<0.001) at 120 minutes, of nucleolar RNA (p<0.001) at 30, 60 and 120 minutes, and of chromosomal RNA (p<0.001) at 60 and 120 minutes. At 60 minutes, there was a pronounced 10-fold increase in incorporation in the 18S region (mRNA) of the gradient of nucleolar RNA of the dietary-restricted group's progeny, which became 3-fold higher at 120 minutes. Radioactivity was lower in chromosomal RNA at 6 and 30 minutes but was considerably higher at 60 and 120 minutes in the dietary-restricted group's offspring compared to the well-fed pups. These data clearly demonstrate that maternal dietary restriction in rats leads to cellular events which increase the synthesis of RNA in the liver of their 21-day-old progeny." @default.
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- W2043282209 date "1990-10-01" @default.
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- W2043282209 title "Maternal dietary deficiency in rats and the in vivo synthesis of cytoplasmic, nucleolar and chromosomal RNA in the liver of their 21-day-old progeny" @default.
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- W2043282209 doi "https://doi.org/10.1016/s0271-5317(05)80341-0" @default.
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