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- W2043283339 abstract "To investigate the origin and nature of the signals responsible for specification of the dermatomal lineage, excised axial organs in 2-day-old chick embryos were replaced by grafts of the dorsal neural tube, or the ventral neural tube plus the notochord, or aggregates of cells engineered to produce Sonic hedgehog (Shh), Noggin, BMP-2, Wnt-1, or Wnt-3a. By E10, grafts of the ventral neural tube plus notochord or of cells producing Shh led to differentiation of cartilage and muscles, and an impaired dermis derived from already segmented somites. In contrast, grafts of the dorsal neural tube, or of cells producing Wnt-1, triggered the formation of a feather-inducing dermis. These results show that the dermatome inducer is produced by the dorsal neural tube. The signal can be Wnt-1 itself, or can be mediated, or at least mimicked by Wnt-1." @default.
- W2043283339 created "2016-06-24" @default.
- W2043283339 creator A5055989986 @default.
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- W2043283339 creator A5076332397 @default.
- W2043283339 creator A5086101561 @default.
- W2043283339 date "2001-02-01" @default.
- W2043283339 modified "2023-10-09" @default.
- W2043283339 title "Dorsal dermis development depends on a signal from the dorsal neural tube, which can be substituted by Wnt-1" @default.
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- W2043283339 doi "https://doi.org/10.1016/s0925-4773(00)00540-2" @default.
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