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- W2043283739 abstract "The mechanisms by which dendritic cells induce Th2 polarization (DCTh2 cells) have been controversial. Many have argued that DCTh2 cells are not a distinct functional DC subset, but rather, DC-induced polarization of Th2 cells is a default pathway that occurs in the absence of inflammatory signals leading to DC-induced polarization of Th1/Th17 cells. However, recent studies demonstrate that distinct subsets of tissue DCs actively polarize Th2 cells after stimulation with type-2 inducing stimuli. DCTh2 cells development is marked by the upregulation of specific transcription factors, cell surface molecules, and cytokines. These findings counter previous hypotheses that Th2 skewing by DCs is a passive response and support a model in which DCs are actively programmed to induce Th2 differentiation." @default.
- W2043283739 created "2016-06-24" @default.
- W2043283739 creator A5069841345 @default.
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- W2043283739 date "2014-12-01" @default.
- W2043283739 modified "2023-10-17" @default.
- W2043283739 title "Distinct dendritic cell subsets actively induce Th2 polarization" @default.
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- W2043283739 doi "https://doi.org/10.1016/j.coi.2014.09.006" @default.
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