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• W2043284863 endingPage "1213" @default.
• W2043284863 startingPage "1193" @default.
• W2043284863 abstract "During the last 20 years, pharmaceutical industry and academic efforts have led to several structurally unrelated classes of non-peptide cholecystokinin-1 receptor (CCK1-R) antagonists. Due to the lack of high resolution structure of CCK1-R and its peptide ligand, different strategies to design antagonists have been adopted. The rational design, based on conformational studies of the endogenous ligand, has provided the so-called ‘peptoid’ derivatives and conformationally restricted peptoids, whereas all of the other non-peptide antagonists derived by empirical and/or conventional approaches, including the chemical manipulation of natural products, disconnection strategies and the use of single key amino acids. All of these strategies include a final optimisation step of the obtained lead compound performed by chemical modifications. The CCK1-R antagonists, in addition to providing a better characterisation of the CCK1-R receptor subtype as pharmacological tools and improving the knowledge of the physiological and pathological role(s) of CCK, may possess therapeutic potential in humans. As the complex biological effects of CCK mediated by CCK1-R in the CNS are not yet completely established, the therapeutic potential of these antagonists at present is limited to the gastrointestinal system disorders. Up until now, loxiglumide and its R-enantiomer (dexloxiglumide) along with lintitript are the CCK1-R antagonists at the most advanced stage of clinical research in gastroenterology." @default.
• W2043284863 created "2016-06-24" @default.
• W2043284863 creator A5034452186 @default.
• W2043284863 creator A5089465265 @default.
• W2043284863 date "2006-08-31" @default.
• W2043284863 modified "2023-10-16" @default.
• W2043284863 title "Twenty years of non-peptide CCK₁receptor antagonists: all that glitters is not gold" @default.
• W2043284863 cites W152590552 @default.
• W2043284863 cites W1690255094 @default.
• W2043284863 cites W169119772 @default.
• W2043284863 cites W180781382 @default.
• W2043284863 cites W1901072364 @default.
• W2043284863 cites W1957048593 @default.
• W2043284863 cites W1964524985 @default.
• W2043284863 cites W1968058596 @default.
• W2043284863 cites W1971463295 @default.
• W2043284863 cites W1977600145 @default.
• W2043284863 cites W1977665929 @default.
• W2043284863 cites W1979100850 @default.
• W2043284863 cites W1981160078 @default.
• W2043284863 cites W1984454399 @default.
• W2043284863 cites W1993122091 @default.
• W2043284863 cites W1993783174 @default.
• W2043284863 cites W1993941573 @default.
• W2043284863 cites W2004647775 @default.
• W2043284863 cites W2007793135 @default.
• W2043284863 cites W2008423468 @default.
• W2043284863 cites W2012697075 @default.
• W2043284863 cites W2013065981 @default.
• W2043284863 cites W2014125926 @default.
• W2043284863 cites W2014297894 @default.
• W2043284863 cites W2015046754 @default.
• W2043284863 cites W2017334065 @default.
• W2043284863 cites W2021394342 @default.
• W2043284863 cites W2022406486 @default.
• W2043284863 cites W2023460491 @default.
• W2043284863 cites W2023512113 @default.
• W2043284863 cites W2027460162 @default.
• W2043284863 cites W2030728069 @default.
• W2043284863 cites W2031461563 @default.
• W2043284863 cites W2033305053 @default.
• W2043284863 cites W2033917087 @default.
• W2043284863 cites W2035912789 @default.
• W2043284863 cites W2036626839 @default.
• W2043284863 cites W2037115273 @default.
• W2043284863 cites W2038552915 @default.
• W2043284863 cites W2044291238 @default.
• W2043284863 cites W2044847871 @default.
• W2043284863 cites W2045594664 @default.
• W2043284863 cites W2046183179 @default.
• W2043284863 cites W2049224383 @default.
• W2043284863 cites W2051034770 @default.
• W2043284863 cites W2052006481 @default.
• W2043284863 cites W2055488727 @default.
• W2043284863 cites W2056570265 @default.
• W2043284863 cites W2059664977 @default.
• W2043284863 cites W2060584233 @default.
• W2043284863 cites W2062785620 @default.
• W2043284863 cites W2063615131 @default.
• W2043284863 cites W2066944012 @default.
• W2043284863 cites W2069835983 @default.
• W2043284863 cites W2070088384 @default.
• W2043284863 cites W2070405487 @default.
• W2043284863 cites W207069409 @default.
• W2043284863 cites W2070812578 @default.
• W2043284863 cites W2071125930 @default.
• W2043284863 cites W2071957690 @default.
• W2043284863 cites W2072341742 @default.
• W2043284863 cites W2073414935 @default.
• W2043284863 cites W2073925618 @default.
• W2043284863 cites W2077187202 @default.
• W2043284863 cites W2077965115 @default.
• W2043284863 cites W2080067185 @default.
• W2043284863 cites W2080986537 @default.
• W2043284863 cites W2084926180 @default.
• W2043284863 cites W2085287792 @default.
• W2043284863 cites W2085642936 @default.
• W2043284863 cites W2086170745 @default.
• W2043284863 cites W2088883811 @default.
• W2043284863 cites W2090177280 @default.
• W2043284863 cites W2090774712 @default.
• W2043284863 cites W2091124211 @default.
• W2043284863 cites W2093800476 @default.
• W2043284863 cites W2093882792 @default.
• W2043284863 cites W2119153622 @default.
• W2043284863 cites W2122856478 @default.
• W2043284863 cites W2128691366 @default.
• W2043284863 cites W2152551546 @default.
• W2043284863 cites W2153880355 @default.
• W2043284863 cites W2154368751 @default.
• W2043284863 cites W2156446121 @default.
• W2043284863 cites W2320455881 @default.
• W2043284863 cites W2341322758 @default.
• W2043284863 cites W2686433753 @default.
• W2043284863 cites W2950105308 @default.
• W2043284863 cites W4296759708 @default.
• W2043284863 cites W4376522322 @default.
• W2043284863 cites W62897627 @default.

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