FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043287085> ?p ?o ?g. }

• W2043287085 endingPage "1598" @default.
• W2043287085 startingPage "1592" @default.
• W2043287085 abstract "Recent studies have shown that morphine, in contrast to other agonists at the mu-opioid receptor, causes very little rapid mu-opioid receptor desensitization or internalization in adult rat mammalian neurons, raising important questions about how morphine tolerance is induced. Here we show that morphine can indeed cause marked rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons when protein kinase C is also activated. Thus, activation of Gq-coupled M3 muscarinic receptors or application of a phorbol ester enhanced the desensitization of the mu-opioid receptor-evoked potassium current in rat locus ceruleus neurons. The enhancement of desensitization was reversible by the protein kinase C inhibitors chelerythrine and 2-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide (GF109203X) and resulted from an effect at the level of the mu-opioid receptor rather than the potassium channel. This is the first finding that morphine can induce rapid mu-opioid receptor desensitization in adult rat neurons, and because reduced protein kinase C activity in vivo attenuates morphine tolerance, we propose that G-protein coupled receptor cross-talk and the level of protein kinase C activity may play critical roles in the desensitization of the mu-opioid receptor and could underlie the development of morphine tolerance." @default.
• W2043287085 created "2016-06-24" @default.
• W2043287085 creator A5024658036 @default.
• W2043287085 creator A5053765063 @default.
• W2043287085 creator A5086304368 @default.
• W2043287085 date "2004-09-10" @default.
• W2043287085 modified "2023-10-16" @default.
• W2043287085 title "Protein Kinase C Activation Enhances Morphine-Induced Rapid Desensitization of μ-Opioid Receptors in Mature Rat Locus Ceruleus Neurons" @default.
• W2043287085 cites W1598320815 @default.
• W2043287085 cites W1655589213 @default.
• W2043287085 cites W1858569662 @default.
• W2043287085 cites W1948374365 @default.
• W2043287085 cites W1967565278 @default.
• W2043287085 cites W1967760715 @default.
• W2043287085 cites W1968901954 @default.
• W2043287085 cites W1973330766 @default.
• W2043287085 cites W1981891173 @default.
• W2043287085 cites W1993258945 @default.
• W2043287085 cites W1997215828 @default.
• W2043287085 cites W2000598928 @default.
• W2043287085 cites W2007174401 @default.
• W2043287085 cites W2011567844 @default.
• W2043287085 cites W2015087988 @default.
• W2043287085 cites W2025030241 @default.
• W2043287085 cites W2025791161 @default.
• W2043287085 cites W2029812913 @default.
• W2043287085 cites W2033525233 @default.
• W2043287085 cites W2044364856 @default.
• W2043287085 cites W2046404790 @default.
• W2043287085 cites W2050601812 @default.
• W2043287085 cites W2051746492 @default.
• W2043287085 cites W2055864420 @default.
• W2043287085 cites W2056550783 @default.
• W2043287085 cites W2057648252 @default.
• W2043287085 cites W2063200179 @default.
• W2043287085 cites W2069717662 @default.
• W2043287085 cites W2081395043 @default.
• W2043287085 cites W2083071923 @default.
• W2043287085 cites W2087139802 @default.
• W2043287085 cites W2125468282 @default.
• W2043287085 cites W2127424619 @default.
• W2043287085 cites W2127605085 @default.
• W2043287085 cites W2131135097 @default.
• W2043287085 cites W2132684873 @default.
• W2043287085 cites W2155088506 @default.
• W2043287085 cites W2155331383 @default.
• W2043287085 cites W2163804310 @default.
• W2043287085 cites W2165498557 @default.
• W2043287085 cites W2169278402 @default.
• W2043287085 cites W4296309414 @default.
• W2043287085 doi "https://doi.org/10.1124/mol.104.004747" @default.
• W2043287085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15361548" @default.
• W2043287085 hasPublicationYear "2004" @default.
• W2043287085 type Work @default.
• W2043287085 sameAs 2043287085 @default.
• W2043287085 citedByCount "91" @default.
• W2043287085 countsByYear W20432870852012 @default.
• W2043287085 countsByYear W20432870852013 @default.
• W2043287085 countsByYear W20432870852014 @default.
• W2043287085 countsByYear W20432870852015 @default.
• W2043287085 countsByYear W20432870852016 @default.
• W2043287085 countsByYear W20432870852017 @default.
• W2043287085 countsByYear W20432870852018 @default.
• W2043287085 countsByYear W20432870852019 @default.
• W2043287085 countsByYear W20432870852020 @default.
• W2043287085 countsByYear W20432870852021 @default.
• W2043287085 countsByYear W20432870852022 @default.
• W2043287085 countsByYear W20432870852023 @default.
• W2043287085 crossrefType "journal-article" @default.
• W2043287085 hasAuthorship W2043287085A5024658036 @default.
• W2043287085 hasAuthorship W2043287085A5053765063 @default.
• W2043287085 hasAuthorship W2043287085A5086304368 @default.
• W2043287085 hasConcept C126322002 @default.
• W2043287085 hasConcept C134018914 @default.
• W2043287085 hasConcept C137183658 @default.
• W2043287085 hasConcept C14397066 @default.
• W2043287085 hasConcept C170493617 @default.
• W2043287085 hasConcept C184235292 @default.
• W2043287085 hasConcept C185592680 @default.
• W2043287085 hasConcept C195794163 @default.
• W2043287085 hasConcept C2776108454 @default.
• W2043287085 hasConcept C2779779143 @default.
• W2043287085 hasConcept C2779886867 @default.
• W2043287085 hasConcept C2780938664 @default.
• W2043287085 hasConcept C2781063702 @default.
• W2043287085 hasConcept C2909480419 @default.
• W2043287085 hasConcept C33235085 @default.
• W2043287085 hasConcept C513476851 @default.
• W2043287085 hasConcept C55493867 @default.
• W2043287085 hasConcept C71924100 @default.
• W2043287085 hasConcept C80631254 @default.
• W2043287085 hasConcept C86803240 @default.
• W2043287085 hasConcept C92759361 @default.
• W2043287085 hasConcept C98274493 @default.
• W2043287085 hasConceptScore W2043287085C126322002 @default.
• W2043287085 hasConceptScore W2043287085C134018914 @default.
• W2043287085 hasConceptScore W2043287085C137183658 @default.
• W2043287085 hasConceptScore W2043287085C14397066 @default.

• next