Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043287112> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2043287112 endingPage "628a" @default.
- W2043287112 startingPage "628a" @default.
- W2043287112 abstract "A plethora of health benefits accompany dietary consumption of ω-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic (EPA, 20:5) and docosahexaenoic (DHA, 22:6) acids found in fish oils. An emerging view for one mechanism of action is that ω-3 PUFA incorporate into phospholipids of the plasma membrane and, due to their aversion for cholesterol, affect lateral organization. What is unclear is which component of fish oil drives the structural and concomitant functional changes. Here we test EPA vs. DHA in mixtures with the lipid raft molecules egg sphingomyelin (SM) and cholesterol. Our approach is to employ solid state 2H NMR to characterize the molecular organization of EPA-containing 1-[2H31]palmitoyl-2- eicosapentaenoylphosphatidylcholine ([2H31]16:0-20:5PC) and DHA-containing 1-[2H31]palmitoyl-2-docosahexaenoylphosphatidylcholine ([2H31]16:0-22:6PC), and of oleic acid (OA, 18:1)-containing 1-[2H31]palmitoyl-2-oleoylphosphatidylcholine ([2H31]16:0-18:1PC) as a control. Spectra for mixtures with SM and cholesterol (1:1:1 mol) support our model according to which poor affinity of PUFA for the sterol promotes the formation of highly disordered PUFA-rich/cholesterol-poor (non-raft) domains on the nanoscale. The novelty of the results lies in the enhanced effect seen for EPA relative to DHA. Less interaction with cholesterol is indicated by the smaller increase in sterol-induced order measured for [2H31]16:0-20:5PC compared to ([2H31]16:0-22:6PC, and a larger domain size is implied with EPA than DHA. We speculate that these preliminary observations at the molecular level may reflect a more influential role for EPA." @default.
- W2043287112 created "2016-06-24" @default.
- W2043287112 creator A5006621736 @default.
- W2043287112 creator A5012197259 @default.
- W2043287112 creator A5021654065 @default.
- W2043287112 creator A5024757186 @default.
- W2043287112 creator A5027879691 @default.
- W2043287112 creator A5034489267 @default.
- W2043287112 date "2011-02-01" @default.
- W2043287112 modified "2023-10-16" @default.
- W2043287112 title "EPA and DHA Interact Differentially with Cholesterol: Solid State 2H NMR of PUFA-Containing Phospholipids in Mixtures with Lipid raft Molecules" @default.
- W2043287112 doi "https://doi.org/10.1016/j.bpj.2010.12.3610" @default.
- W2043287112 hasPublicationYear "2011" @default.
- W2043287112 type Work @default.
- W2043287112 sameAs 2043287112 @default.
- W2043287112 citedByCount "0" @default.
- W2043287112 crossrefType "journal-article" @default.
- W2043287112 hasAuthorship W2043287112A5006621736 @default.
- W2043287112 hasAuthorship W2043287112A5012197259 @default.
- W2043287112 hasAuthorship W2043287112A5021654065 @default.
- W2043287112 hasAuthorship W2043287112A5024757186 @default.
- W2043287112 hasAuthorship W2043287112A5027879691 @default.
- W2043287112 hasAuthorship W2043287112A5034489267 @default.
- W2043287112 hasBestOaLocation W20432871121 @default.
- W2043287112 hasConcept C15920480 @default.
- W2043287112 hasConcept C178790620 @default.
- W2043287112 hasConcept C185592680 @default.
- W2043287112 hasConcept C19038510 @default.
- W2043287112 hasConcept C2776091944 @default.
- W2043287112 hasConcept C2777171753 @default.
- W2043287112 hasConcept C2778163477 @default.
- W2043287112 hasConcept C2778718757 @default.
- W2043287112 hasConcept C2779946292 @default.
- W2043287112 hasConcept C2909208804 @default.
- W2043287112 hasConcept C31903555 @default.
- W2043287112 hasConcept C505870484 @default.
- W2043287112 hasConcept C521977710 @default.
- W2043287112 hasConcept C543025807 @default.
- W2043287112 hasConcept C55493867 @default.
- W2043287112 hasConcept C61322309 @default.
- W2043287112 hasConcept C61705674 @default.
- W2043287112 hasConcept C79266657 @default.
- W2043287112 hasConcept C86803240 @default.
- W2043287112 hasConcept C9132879 @default.
- W2043287112 hasConceptScore W2043287112C15920480 @default.
- W2043287112 hasConceptScore W2043287112C178790620 @default.
- W2043287112 hasConceptScore W2043287112C185592680 @default.
- W2043287112 hasConceptScore W2043287112C19038510 @default.
- W2043287112 hasConceptScore W2043287112C2776091944 @default.
- W2043287112 hasConceptScore W2043287112C2777171753 @default.
- W2043287112 hasConceptScore W2043287112C2778163477 @default.
- W2043287112 hasConceptScore W2043287112C2778718757 @default.
- W2043287112 hasConceptScore W2043287112C2779946292 @default.
- W2043287112 hasConceptScore W2043287112C2909208804 @default.
- W2043287112 hasConceptScore W2043287112C31903555 @default.
- W2043287112 hasConceptScore W2043287112C505870484 @default.
- W2043287112 hasConceptScore W2043287112C521977710 @default.
- W2043287112 hasConceptScore W2043287112C543025807 @default.
- W2043287112 hasConceptScore W2043287112C55493867 @default.
- W2043287112 hasConceptScore W2043287112C61322309 @default.
- W2043287112 hasConceptScore W2043287112C61705674 @default.
- W2043287112 hasConceptScore W2043287112C79266657 @default.
- W2043287112 hasConceptScore W2043287112C86803240 @default.
- W2043287112 hasConceptScore W2043287112C9132879 @default.
- W2043287112 hasIssue "3" @default.
- W2043287112 hasLocation W20432871121 @default.
- W2043287112 hasOpenAccess W2043287112 @default.
- W2043287112 hasPrimaryLocation W20432871121 @default.
- W2043287112 hasRelatedWork W1974388771 @default.
- W2043287112 hasRelatedWork W1976989322 @default.
- W2043287112 hasRelatedWork W1982194308 @default.
- W2043287112 hasRelatedWork W1998520778 @default.
- W2043287112 hasRelatedWork W2025529482 @default.
- W2043287112 hasRelatedWork W2035697025 @default.
- W2043287112 hasRelatedWork W2043287112 @default.
- W2043287112 hasRelatedWork W2071127617 @default.
- W2043287112 hasRelatedWork W2117379166 @default.
- W2043287112 hasRelatedWork W2744451750 @default.
- W2043287112 hasVolume "100" @default.
- W2043287112 isParatext "false" @default.
- W2043287112 isRetracted "false" @default.
- W2043287112 magId "2043287112" @default.
- W2043287112 workType "article" @default.