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• W2043287555 abstract "Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant condition caused by mutations in the FLCN gene and characterized by benign hair follicle tumors, pneumothorax, and renal cancer. Folliculin (FLCN), the protein product of the FLCN gene, is a poorly characterized tumor suppressor protein, currently linked to multiple cellular pathways. Autophagy maintains cellular homeostasis by removing damaged organelles and macromolecules. Although the autophagy kinase ULK1 drives autophagy, the underlying mechanisms are still being unraveled and few ULK1 substrates have been identified to date. Here, we identify that loss of FLCN moderately impairs basal autophagic flux, while re-expression of FLCN rescues autophagy. We reveal that the FLCN complex is regulated by ULK1 and elucidate 3 novel phosphorylation sites (Ser406, Ser537, and Ser542) within FLCN, which are induced by ULK1 overexpression. In addition, our findings demonstrate that FLCN interacts with a second integral component of the autophagy machinery, GABA(A) receptor-associated protein (GABARAP). The FLCN-GABARAP association is modulated by the presence of either folliculin-interacting protein (FNIP)-1 or FNIP2 and further regulated by ULK1. As observed by elevation of GABARAP, sequestome 1 (SQSTM1) and microtubule-associated protein 1 light chain 3 (MAP1LC3B) in chromophobe and clear cell tumors from a BHD patient, we found that autophagy is impaired in BHD-associated renal tumors. Consequently, this work reveals a novel facet of autophagy regulation by ULK1 and substantially contributes to our understanding of FLCN function by linking it directly to autophagy through GABARAP and ULK1." @default.
• W2043287555 created "2016-06-24" @default.
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• W2043287555 date "2014-07-22" @default.
• W2043287555 modified "2023-10-01" @default.
• W2043287555 title "FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation" @default.
• W2043287555 cites W1754519657 @default.
• W2043287555 cites W1918384196 @default.
• W2043287555 cites W1970637701 @default.
• W2043287555 cites W1973884972 @default.
• W2043287555 cites W1975924645 @default.
• W2043287555 cites W1977721235 @default.
• W2043287555 cites W1978397479 @default.
• W2043287555 cites W1980955874 @default.
• W2043287555 cites W1983393050 @default.
• W2043287555 cites W1984537066 @default.
• W2043287555 cites W1987614211 @default.
• W2043287555 cites W1987769185 @default.
• W2043287555 cites W1990834080 @default.
• W2043287555 cites W1995455069 @default.
• W2043287555 cites W1995771017 @default.
• W2043287555 cites W1996098861 @default.
• W2043287555 cites W1997836389 @default.
• W2043287555 cites W1999211990 @default.
• W2043287555 cites W2001160077 @default.
• W2043287555 cites W2003010123 @default.
• W2043287555 cites W2014918593 @default.
• W2043287555 cites W2022812113 @default.
• W2043287555 cites W2026465178 @default.
• W2043287555 cites W2030430693 @default.
• W2043287555 cites W2032848771 @default.
• W2043287555 cites W2036568535 @default.
• W2043287555 cites W2041491503 @default.
• W2043287555 cites W2045373134 @default.
• W2043287555 cites W2046447620 @default.
• W2043287555 cites W2055197266 @default.
• W2043287555 cites W2057530007 @default.
• W2043287555 cites W2059185581 @default.
• W2043287555 cites W2060438440 @default.
• W2043287555 cites W2063761428 @default.
• W2043287555 cites W2067683713 @default.
• W2043287555 cites W2068153705 @default.
• W2043287555 cites W2073824006 @default.
• W2043287555 cites W2073963703 @default.
• W2043287555 cites W2078594804 @default.
• W2043287555 cites W2083087851 @default.
• W2043287555 cites W2085442981 @default.
• W2043287555 cites W2086096948 @default.
• W2043287555 cites W2086327073 @default.
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• W2043287555 cites W2100902550 @default.
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• W2043287555 cites W2150815806 @default.
• W2043287555 cites W2151129273 @default.
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• W2043287555 cites W2157638939 @default.
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• W2043287555 doi "https://doi.org/10.4161/auto.29640" @default.
• W2043287555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4198360" @default.
• W2043287555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25126726" @default.
• W2043287555 hasPublicationYear "2014" @default.
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